Low vitamin and carotenoid levels are related to cerebral white matter lesions.
Low vitamin and carotenoid levels are related to cerebral white matter lesions.
复制标题
维生素和类胡萝卜素水平低与脑白质病变有关。
DOI：
10.1007/s12603-012-0427-z
复制
发表时间：
2013
影响因子：
5.8
通讯作者：
Watanabe Y.
中科院分区：
文献类型：
--
作者：
Ohshima Y;Mizuno T;Yamada K;Matsumoto S;Nagakane Y;Kondo M;Kuriyama;Miyazaki T;Takeda K;Nishimura T;Nakagawa M;Ozasa K;Watanabe Y.
目的：PurposeTo确定维生素和类胡萝卜素对脑白色物质病变（WML）的影响，我们研究了日本中年和老年subjects.Subjects和methodsFour-hundred和69名健康参与者（男性= 317;女性= 152），接受医疗检查的WML与维生素和类胡萝卜素水平之间的关联。通过磁共振成像（MRI）在39名受试者中检测到深部白色病变（DWLs）。我们评估了维生素和类胡萝卜素水平对DWLs的影响，通过Logistic回归analysis.ResultsLower γ-生育酚水平显着相关DWLs在所有科目。虽然较低的γ-生育酚和维生素C水平与男性的DWLs显著相关，但较低的δ-生育酚水平与女性的DWLs相关。DWLs与较低的γ-和δ-生育酚和维生素C水平之间的关联与年龄、高血压或吸烟无关。然而，DWLs和低α-生育酚之间的关联并不显着调整smoking.ConclusionLower类胡萝卜素和维生素水平独立与脑DWLs在日本受试者。
Objectives: PurposeTo determine the effects of vitamins and carotenoids on brain white matter lesions (WMLs), we examined the associations between WMLs with vitamin and carotenoid levels in Japanese middle-aged and elderly subjects.Subjects and methodsFour-hundred and sixty-nine healthy participants (male = 317; female = 152) that underwent medical examinations were examined. Deep white matter lesions (DWLs) were detected via magnetic resonance imaging (MRI) in 39 subjects. We evaluated the effects of vitamin and carotenoid levels on DWLs via logistic regression analysis.ResultsLower gamma-tocopherol levels were significantly associated with DWLs in all subjects. While lower gamma-tocopherol and vitamin C levels were significantly associated with DWLs in males, lower delta-tocopherol levels were associated with DWLs in females. The associations between DWLs and lower gamma- and delta-tocopherol and vitamin C levels were independent of age, hypertension, or smoking. However, the associations between DWLs and lower alfatocopherol were not significant following adjustments for smoking.ConclusionLower carotenoid and vitamin levels were independently associated with cerebral DWLs in Japanese subjects.