Kidney stones and the risk of renal cell carcinoma and upper tract urothelial carcinoma: the Netherlands Cohort Study
Kidney stones and the risk of renal cell carcinoma and upper tract urothelial carcinoma: the Netherlands Cohort Study
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DOI：
10.1038/s41416-018-0356-7
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发表时间：
2019-02-05
影响因子：
8.8
通讯作者：
Schouten, Leo J.
中科院分区：
文献类型：
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作者：
van de Pol, Jeroen A. A.;van den Brandt, Piet A.;Schouten, Leo J.
背景：我们在荷兰关于饮食和癌症的队列研究中研究了肾结石与肾细胞癌 (RCC) 和上尿路尿路上皮癌 (UTUC) 风险之间的关联。 方法：总共 120,852 名 55-69 岁的参与者在基线 (1986 年) 完成了一份关于饮食、医疗状况和其他癌症危险因素的自填问卷。经过 20.3 年的癌症随访，4352 名亚队列成员、544 名 RCC 病例和 140 名 UTUC 病例符合病例队列分析的条件。通过多变量调整比例风险模型估算风险比 (HR) 和 95% 置信区间 (CI)。 结果：与无肾结石相比，肾结石与 RCC 风险增加相关（HR：1.39，95% CI 1.05-1.84）。肾结石与乳头状肾细胞癌风险增加相关（HR：3.08，95% CI 1.55-6.11），但与透明细胞肾细胞癌风险增加无关（HR：1.14，95% CI 0.79-1.65）。患有肾结石的参与者的 UTUC 风险增加（HR：1.66，95% CI 1.03-2.68）。输尿管和肾盂中的 UTUC 未发现关联的异质性。早期肾结石诊断（
BACKGROUND: We examined the association between kidney stones and renal cell carcinoma (RCC) and upper tract urothelial carcinoma (UTUC) risk in the Netherlands Cohort Study on diet and cancer.METHODS: In total, 120,852 participants aged 55-69 completed a self-administered questionnaire on diet, medical conditions and other risk factors for cancer at baseline (1986). After 20.3 years of cancer follow-up 4352 subcohort members, 544 RCC cases and 140 UTUC cases were eligible for case-cohort analysis. Hazard ratios (HR) and 95% confidence intervals (CIs) were estimated by multivariable-adjusted proportional hazards models.RESULTS: Kidney stones were associated with an increased RCC risk (HR: 1.39, 95% CI 1.05-1.84), vs. no kidney stones. Kidney stones were associated with an increased risk of papillary RCC (HR: 3.08, 95% CI 1.55-6.11), but not clear-cell RCC (HR: 1.14, 95% CI 0.79-1.65). UTUC risk was increased for participants with kidney stones (HR: 1.66, 95% CI 1.03-2.68). No heterogeneity of associations was found for UTUC in the ureter and renal pelvis. An early kidney stone diagnosis (