Procedural and declarative memory task performance, and the memory consolidation function of sleep, in recent and abstinent ecstasy/MDMA users
Procedural and declarative memory task performance, and the memory consolidation function of sleep, in recent and abstinent ecstasy/MDMA users
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DOI：
10.1177/0269881110372545
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发表时间：
2011-04-01
影响因子：
4.1
通讯作者：
Morgan, Michael J.
中科院分区：
文献类型：
--
作者：
Blagrove, Mark;Seddon, Jennifer;Morgan, Michael J.
摇头丸/MDMA的使用与各种记忆缺陷有关。本研究评估了摇头丸/MDMA使用者的陈述性和程序性记忆。参与者被分为两个阶段进行测试，间隔24小时，因此也可以评估睡眠对两种类型记忆的记忆巩固功能。分组为：未使用过药物的对照组（n = 24）;最近使用过摇头丸/MDMA的人，在第一次测试前2-3天使用过摇头丸/MDMA（n = 25），以及在测试前至少8天未使用摇头丸/MDMA的戒断者（n = 17）。程序性记忆在两组之间没有差异，但一生中大量服用摇头丸与较差的程序性记忆有关。在测试前48- 24小时服用其他药物（主要是大麻）的近期摇头丸/MDMA使用者的陈述性记忆比对照组差，但在这48-24小时内未服用其他药物的近期使用者与对照组没有差异。一生中大量服用摇头丸和可卡因与陈述性记忆的缺陷有关。这些结果表明，程序性以及陈述性记忆缺陷与过去使用摇头丸的程度有关。然而，摇头丸/MDMA并没有影响睡眠的记忆巩固功能的陈述性或程序性记忆任务。
Ecstasy/MDMA use has been associated with various memory deficits. This study assessed declarative and procedural memory in ecstasy/MDMA users. Participants were tested in two sessions, 24 h apart, so that the memory consolidation function of sleep on both types of memory could also be assessed. Groups were: drug-naive controls (n = 24); recent ecstasy/MDMA users, who had taken ecstasy/MDMA 2-3 days before the first testing session (n = 25), and abstinent users, who had not taken ecstasy/MDMA for at least 8 days before testing (n = 17). Procedural memory did not differ between groups, but greater lifetime consumption of ecstasy was associated with poorer procedural memory. Recent ecstasy/MDMA users who had taken other drugs (mainly cannabis) 48-24 h before testing exhibited poorer declarative memory than controls, but recent users who had not taken other drugs in this 48-24-h period did not differ from controls. Greater lifetime consumption of ecstasy, and of cocaine, were associated with greater deficits in declarative memory. These results suggest that procedural, as well as declarative, memory deficits are associated with the extent of past ecstasy use. However, ecstasy/MDMA did not affect the memory consolidation function of sleep for either the declarative or the procedural memory task.