Simultaneous visualization of multiple radionuclides in vivo
Simultaneous visualization of multiple radionuclides in vivo
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DOI：
10.1038/s41551-022-00866-6
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发表时间：
2022-04-04
影响因子：
28.1
通讯作者：
Fujii, Hirofumi
中科院分区：
文献类型：
--
作者：
Yagishita, Atsushi;Takeda, Shin'ichiro;Fujii, Hirofumi
常规闪烁探测器的放射性核素成像的能量和空间分辨率不足，限制了组织中多种放射性核素和微结构的可视化。在这里，我们报告的发展和性能的成像系统配备了碲化镉二极管探测器，实现了1.7%的能量分辨率在140千电子伏和250 μ m的空间分辨率。高分辨率光谱的组合适合于X射线分析模型的放射性核素的发射线在一个选定的能带，使我们能够准确地确定个人的辐射活动，从三个放射性核素，同时可视化甲状腺组织（通过静脉注射碘-125），小鼠下颌淋巴结（通过肌肉注射铟-111）和腮腺淋巴结（通过皮下注射锝-99m）。多放射性核素成像可以在生物医学成像中找到有利的应用。多个放射性核素可以通过成像系统在体内同时可视化，该成像系统提供高分辨率光谱，然后将其拟合到放射性核素在所选能带中的发射线的X射线分析模型。
The insufficient energy and spatial resolutions of radionuclide imaging with conventional scintillation detectors restrict the visualization of multiple radionuclides and of microstructures in tissue. Here we report the development and performance of an imaging system equipped with a cadmium telluride diode detector that achieves an energy resolution of 1.7% at 140 keV and a spatial resolution of 250 mu m. The combination of high-resolution spectra fitted to an X-ray analysis model of the emission lines of the radionuclides in a chosen energy band allowed us to accurately determine individual radiation activities from three radionuclides to simultaneously visualize thyroid tissue (via intravenously administered iodine-125), mandibular lymph nodes (via the intramuscular injection of indium-111) and parotid lymph nodes (via a subcutaneous injection of technetium-99m) in mice. Multi-radionuclide imaging may find advantageous applications in biomedical imaging.Multiple radionuclides can be simultaneously visualized in vivo by an imaging system providing high-resolution spectra that are then fitted to an X-ray analysis model of the emission lines of the radionuclides in the chosen energy band.