Simultaneous Hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 Dogs with Cancer
Simultaneous Hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 Dogs with Cancer
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DOI：
10.2967/jnumed.115.156364
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发表时间：
2015-11-01
影响因子：
9.3
通讯作者：
Kjaer, Andreas
中科院分区：
文献类型：
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作者：
Gutte, Henrik;Hansen, Adam E.;Kjaer, Andreas
随着PET/MR （MRS）联合成像技术的引入，现在可以通过超极化c -13-丙酮酸和F-18-FDG PET成像技术分别直接和间接地成像Warburg效应，我们将这种技术命名为hyperPET。本研究的主要目的是建立一个实用的工作流程，同时进行F-18-FDG PET和超极化c -13-丙酮酸MRS成像，用于肿瘤组织表征，并在更大规模上测试其可行性。此外，我们评估了F-18-FDG摄取与c -13-乳酸生成之间的相关性。方法：选取10只经活检证实的自发性恶性肿瘤犬进行影像学检查。所有的狗都接受了同时进行的F-18-FDG PET、解剖MR和c -13-丙酮酸成像的超极化动态核极化。数据是通过联合临床PET/MR成像扫描仪获得的。结果：我们发现F-18-FDG PET和c -13-丙酮酸酯MRS成像可以在大约2小时的单次成像中进行。当狗被放置在PET/MR扫描仪中时，注射F-18-FDG获得了连续的工作流程。C-13-MRS动态采集显示，10只狗中有9只增加了c -13-乳酸生成。9只狗的c -13-乳酸平均在25 s（范围17-33 s）后检测到，平均在49 s（范围40-62 s）达到峰值。c -13-丙酮酸的平均检测时间为13 s（范围5 ~ 26 s），平均检测时间为25 s（范围13 ~ 42 s）达到峰值。我们注意到，在大多数（但不是全部）轴向切片中，F-18-FDG的摄取和c -13-乳酸盐的产生是一致的。结论：在这项研究中，我们在一系列患有癌症的狗身上发现，超pet可以在2小时内很容易地进行。我们发现c -13-乳酸生成和F-18-FDG摄取之间的大部分对应关系，并期望联合方式揭示额外的代谢信息，以提高预后价值和改善反应监测。
With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized C-13-pyruvate and F-18-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study was to establish a practical workflow for performing F-18-FDG PET and hyperpolarized C-13-pyruvate MRS imaging simultaneously for tumor tissue characterization and on a larger scale test its feasibility. In addition, we evaluated the correlation between F-18-FDG uptake and C-13-lactate production. Methods: Ten dogs with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous F-18-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with C-13-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner. Results: We found that combined F-18-FDG PET and C-13-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of F-18-FDG when the dogs was placed in the PET/MR scanner. C-13-MRS dynamic acquisition demonstrated in an axial slab increased C-13-lactate production in 9 of 10 dogs. For the 9 dogs, the C-13-lactate was detected after a mean of 25 s (range, 17-33 s), with a mean to peak of C-13-lactate at 49 s (range, 40-62 s). C-13-pyruvate could be detected on average after 13 s (range, 5-26 s) and peaked on average after 25 s (range, 13-42 s). We noticed concordance of F-18-FDG uptake and production of C-13-lactate in most, but not all, axial slices. Conclusion: In this study, we have shown in a series of dogs with cancer that hyperPET can easily be performed within 2 h. We showed mostly correspondence between C-13-lactate production and F-18-FDG uptake and expect the combined modalities to reveal additional metabolic information to improve prognostic value and improve response monitoring.