A rare case of feline congenital Toxoplasma gondii infection: fatal outcome of systemic toxoplasmosis for the mother and its kitten
A rare case of feline congenital Toxoplasma gondii infection: fatal outcome of systemic toxoplasmosis for the mother and its kitten
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DOI：
10.2376/0005-9366-126-216
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发表时间：
2013-05-01
影响因子：
0.4
通讯作者：
Kul, Oguz
中科院分区：
文献类型：
--
作者：
Atmaca, Hasan Tarik;Dincel, Gungor Cagdas;Kul, Oguz
本文报告一例2.5岁的混合品种怀孕猫及其小猫的致命性系统性弓形虫病。妊娠猫因难产症状就诊于妇科诊所。超声波检查显示子宫内有5个胎儿，其中3个已经死亡，因此进行了剖腹产。然而，母猫和剩下的两只活小猫分别在剖腹产后两天和十天死亡。病理学上，母猫肺泡水肿严重，肺泡巨噬细胞内可见速殖子样结构，肺内可见多灶性坏死。在肺泡巨噬细胞、支气管和细支气管上皮细胞、肺坏死灶和肝枯否细胞的细胞内观察到强烈的弓形虫免疫阳性反应。PCR扩增T.母猫和小猫组织样本中的弓形虫DNA。本研究为T.弓形虫感染对母猫、胎儿和小猫有致命后果。据作者所知，这是土耳其首例家猫先天性弓形虫病致死病例。
This report describes a case of fatal systemic toxoplasmosis in a 2.5-year-old mixed breed pregnant cat and its kittens. The pregnant cat was presented to the gynecology clinic with symptoms of dystocia. The ultrasound examination revealed the presence of five fetuses in the uterus, three of which were not alive, and consequently a cesarean section was performed. However, the mother cat and the remaining two live kittens died two and ten days after cesarean section, respectively. Pathologically, severe alveolar edema, tachyzoite-like structures in the alveolar macrophages and multifocal necroses in the lungs of mother cat were observed. An intense Toxoplasma gondii immunopositive reaction was observed in the cytoplasms of alveolar macrophages, bronchial and bronchiolar epithelia, necrotic foci in the lungs, and Kupffer cells of the liver. PCR analyses amplified T. gondii DNA in tissue samples of the mother cat and kittens. The present study provides strong evidence for a transplacental transmission of T. gondii infection with deadly outcome for the mother cat, fetuses and kittens. As to the authors' knowledge, this report is the first case of fatal congenital toxoplasmosis in domestic cats in Turkey.