Endotracheal Tube Biofilm and Ventilator-Associated Pneumonia With Mechanical Ventilation
Endotracheal Tube Biofilm and Ventilator-Associated Pneumonia With Mechanical Ventilation
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DOI：
10.1002/jemt.22344
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发表时间：
2014-04-01
影响因子：
2.5
通讯作者：
Watanabe, Evandro
中科院分区：
文献类型：
--
作者：
De Souza, Paula Regina;De Andrade, Denise;Watanabe, Evandro
目的：分析重症监护患者使用气管插管后气管插管内外表面的生物膜，并提供插管使用、生物膜存在和肺炎发生之间相关性的证据。方法：这是一项在巴西圣保罗州内陆一家急诊医院重症监护室进行的临床研究。数据收集涉及30支气管内导管用于成人患者的48小时的机械通气扫描电子显微镜。结果如下：通过扫描电子显微镜对30个管上的生物膜的分析显示了各种非生物和生物结构，主要在内表面上，例如：纤维蛋白网络、红细胞、白细胞、球菌、杆菌和霉菌等。气管插管时间8天是呼吸机相关性肺炎的危险因素之一（RR 7.41，P
Objective: To analyze biofilm on internal and external surfaces of endotracheal tubes after their use in critical care patients, and to produce evidence of association between use of the tube, presence of biofilm, and the occurrence of pneumonia. Methods: This was a clinical study performed at the Intensive Care Unit of an emergency hospital in the interior of SAo Paulo state, Brazil. Data collection involved 30 endotracheal tubes used on adult patients for a period of 48 h of mechanical ventilation for scanning electron microscopy. Results: Analysis of the biofilm on the 30 tubes by scanning electron microscopy showed various abiotic and biotic structures, predominately on the internal surface, such as: fibrin network, erythrocytes, leukocytes, cocci, bacilli, and molds, among others. The intubation period of the endotracheal tube for 8 days represented one of the risk factors for ventilator-associated pneumonia (RR 7.41, P