Heterogeneity of release probability, facilitation, and depletion at central synapses
Heterogeneity of release probability, facilitation, and depletion at central synapses
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DOI：
10.1016/s0896-6273(00)80338-4
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发表时间：
1997-06-01
期刊：
影响因子：
16.2
通讯作者：
Stevens, CF
中科院分区：
文献类型：
--
作者：
Dobrunz, LE;Stevens, CF
Previous studies of short-term plasticity in central nervous systems synapses have largely focused on average synaptic properties. In this study, we use recordings from putative single synaptic release sites in hippocampal slices to show that significant heterogeneity exists in facilitation and depletion among synapses. In particular, the amount of paired-pulse facilitation is inversely related to the initial release probability of the synapse. We also examined depletion at individual synapses using high frequency stimulation, and estimated the size of the readily releasable vesicle pool, which averaged 5.0 +/- 3.0 quanta (n = 13 synapses). In addition, these experiments demonstrate that the release probability at a synapse is directly correlated with the size of its readily releasable vesicle pool.
