Different phosphorylation rates among vertebrate cone visual pigments with different spectral sensitivities
Different phosphorylation rates among vertebrate cone visual pigments with different spectral sensitivities
复制标题
不同光谱敏感性的脊椎动物视锥视色素的磷酸化率不同
DOI：
10.1016/j.bbrc.2013.09.118
复制
发表时间：
2013
影响因子：
3.1
通讯作者：
S.
中科院分区：
文献类型：
--
作者：
Tsutsui;K.;Tachibanaki;S.;Shimauchi-Matsukawa;Y.;Shichida;Y.;and Kawamura;S.
在一些脊椎动物中，具有不同光谱敏感性的视锥细胞光感受器亚型在其光响应中表现出不同的恢复动力学。 G 蛋白偶联受体激酶 (GRK) 的磷酸化对于光激活视色素的快速失活至关重要，这是蝾螈视锥细胞光响应恢复的限速步骤。在本研究中，我们比较了鲤鱼绿色和蓝色敏感视锥视色素的 GRK7 的光依赖性磷酸化速率。蓝色色素的磷酸化效率明显低于绿色色素，这表明色素磷酸化率的差异是视锥光感受器亚型之间光响应动力学差异的原因。
Cone photoreceptor subtypes having different spectral sensitivities exhibit different recovery kinetics in their photoresponses in some vertebrates. Phosphorylation by G protein-coupled receptor kinase (GRK) is essential for the rapid inactivation of light-activated visual pigment, which is the rate-limiting step of the cone photoresponse recovery in salamander. In this study we compared the rate of light-dependent phosphorylation by GRK7 of carp green- and blue-sensitive cone visual pigments. Blue pigment was phosphorylated significantly less effectively than green pigment, suggesting that the difference in the pigment phosphorylation rate is responsible for the difference in photoresponse kinetics among cone photoreceptor subtypes.