Discrimination of basal cell carcinoma from benign lesions based on extraction of ulcer features in polarized-light dermoscopy images.
Discrimination of basal cell carcinoma from benign lesions based on extraction of ulcer features in polarized-light dermoscopy images.
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DOI：
10.1111/j.1600-0846.2011.00595.x
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Stoecker WV
中科院分区：
文献类型：
--
作者：
Kefel S;Guvenc P;LeAnder R;Stricklin SM;Stoecker WV
在基底细胞癌的皮肤镜图像中，溃疡经常可见。没有创伤史的溃疡，即所谓的“非创伤性”溃疡，是基底细胞癌的重要标志，基底细胞癌是最常见的皮肤癌。将此类溃疡与良性病变中发现的类似特征区分开来具有挑战性。在这项研究中，溃疡的颜色和纹理特征进行分析，以区分基底细胞癌良性病变。在49例活检证实的基底细胞癌的偏振光皮肤镜图像中识别并手动选择溃疡。对于153例良性病变的偏振光皮肤镜图像，同样选择最接近溃疡的区域。在溃疡和溃疡模拟区域分析了15项指标。其中六项是纹理度量：能量、方差、平滑度、偏斜度、均匀度和熵。其中9项是颜色测量：红色、绿色和蓝色的相对测量;红色、绿色和蓝色的色度;以及蓝色与绿色、蓝色与红色和绿色与红色的比率。反向传播人工神经网络能够区分大多数的基底细胞癌良性病变，ROC曲线下的面积高达92.46%，使用颜色和纹理特征的溃疡面积。通过图像分析技术将基底细胞癌从良性皮肤病变中分离出来是可行的。由于溃疡是恶性病变的一个重要特征，这一发现可能在基底细胞癌的自动检测中有应用。
Ulcers are frequently visible in magnified, cross-polarized, dermoscopy images of basal cell carcinoma. An ulcer without a history of trauma, a so-called “atraumatic” ulcer, is an important sign of basal cell carcinoma, the most common skin cancer. Distinguishing such ulcers from similar features found in benign lesions is challenging. In this research, color and texture features of ulcers are analyzed to discriminate basal cell carcinoma from benign lesions. Ulcers in polarized-light dermoscopy images of 49 biopsy-proven basal cell carcinomas were identified and manually selected. For 153 polarized-light dermoscopy images of benign lesions, those areas which most closely mimicked ulcers were similarly selected. Fifteen measures were analyzed over the areas of ulcers and ulcer mimics. Six of those measures were texture measures: energy, variance, smoothness, skewness, uniformity and entropy. Nine of those measures were color measures: relative measures of red, green and blue; chromaticity of red, green and blue; and the ratios blue-to-green, blue-to-red and green-to-red. A back-propagation artificial neural network was able to discriminate most of the basal cell carcinoma from benign lesions, with an area under the ROC curve as high as 92.46%, using color and texture features of ulcer areas. Separation of basal cell carcinoma from benign cutaneous lesions by image analysis techniques applied to ulcers is feasible. As ulcers are a critical feature in malignant lesions, this finding may have application in the automatic detection of basal cell carcinoma.
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影响因子：
--
作者：
UMBAUGH, SE;MOSS, RH;STOECKER, WV
通讯作者：
STOECKER, WV
影响因子：
--
作者：
Benvenuto-Andrade, Cristiane;Dusza, Stephen W.;Marghoob, Ashfaq A.
通讯作者：
Marghoob, Ashfaq A.
DOI：
10.3109/17453059609018381
发表时间：
1996-03-01
期刊：
The Journal of audiovisual media in medicine
影响因子：
--
作者：
McFall, K
通讯作者：
McFall, K
影响因子：
5.7
作者：
Celebi, M. Emre;Iyatomi, Hitoshi;Stoecker, William V.;Moss, Randy H.;Rabinovitz, Harold S.;Argenziano, Giuseppe;Soyer, H. Peter
通讯作者：
Soyer, H. Peter
影响因子：
3.5
作者：
Bowling, F. L.;King, L.;Boulton, A. J. M.
通讯作者：
Boulton, A. J. M.