Testis histopathology in boys with cryptorchidism correlates with future fertility potential
Testis histopathology in boys with cryptorchidism correlates with future fertility potential
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DOI：
10.1016/s0022-5347(05)63986-9
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发表时间：
2003-02-01
影响因子：
6.6
通讯作者：
Canning, DA
中科院分区：
文献类型：
--
作者：
Rusnack, SL;Wu, HY;Canning, DA
目的：我们研究睾丸活检预测最终生育能力的能力。材料与方法：共有25例单侧隐睾患者和11例双侧隐睾患者在中位年龄9岁时接受过睾丸固定术，随访至18岁。将精液分析、睾丸体积、卵泡刺激素、黄体生成素、睾酮和睾酮B与先前获得的每个睾丸活检进行比较。活检分为轻度，中度或严重的组织学正常和隐睾histology.Results发表的数据为基础：单侧隐睾和中度组织学的患者更有可能有一个精子密度大于20万每cc比那些严重的组织学（p = 0.006），虽然没有显着差异的激素参数。双侧隐睾和中度组织学的患者比重度组织学的患者更可能具有正常的卵泡刺激素和卵泡刺激素B（分别为p = 0.05和0.002），尽管没有观察到精液分析的差异。总体而言，9例双侧隐睾患者中有7例的精子数低于20万/cc。结论：睾丸活检提供了有用的预后信息，单侧隐睾患者的精液分析。9例双侧隐睾患者睾丸活检按激素水平分为正常组和异常组。睾丸活检不能提供额外的预后信息，精液分析双侧隐睾患者，因为他们都是穷人。
Purpose: We studied the ability of testis biopsy to predict eventual fertility potential. Materials and Methods: A total of 25 patients with unilateral undescended testis and 11 with bilateral undescended testes who previously underwent orchiopexy at a median age of 9 years were followed until after age 18 years. Semen analysis, testicular volume, follicle-stimulating hormone, luteinizing hormone, testosterone and inhibin B were compared to previously obtained biopsies of each testis. Biopsies were graded as mild, moderate or severe histology based on published data for normal and undescended testis histology.Results: Patients with unilateral undescended testis and moderate histology were more likely to have a sperm density of greater than 20 million per cc than those with severe histology (p = 0.006), although no difference in hormonal parameters was noted. Patients with bilateral undescended testes and moderate histology were more likely to have normal follicle-stimulating hormone and inhibin B than those with severe histology (p = 0.05 and 0.002, respectively), although no difference in semen analysis was observed. Overall 7 of the 9 patients with bilateral undescended testes had less than 20 million sperm per cc.Conclusions: Testis biopsy provides useful prognostic information about semen analysis in patients with unilateral undescended testis. In the 9 patients with bilateral undescended testes testis biopsy divided them into normal and abnormal groups in terms of hormonal parameters. Testis biopsy was not able to provide additional prognostic information on semen analysis in patients with bilateral undescended testes since they were uniformly poor.