Vascular disease in pre-diabetes: new insights derived from systems biology.
Vascular disease in pre-diabetes: new insights derived from systems biology.
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发表时间：
2010-07
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通讯作者：
R. Sprague;M. Ellsworth
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作者：
R. Sprague;M. Ellsworth
在许多情况下，血管疾病在2型糖尿病的临床发作之前存在，即在胰岛素水平显著增加的糖尿病前期期间。在糖尿病前期，微血管功能障碍与血浆胰岛素水平相关，而不是血糖。在这里，我们讨论的概念，胰岛素，在糖尿病前期发现的水平，有助于骨骼肌微血管疾病，抑制释放的血管扩张剂，三磷酸腺苷（ATP），从红细胞。
In many cases vascular disease is present before the clinical onset of type 2 diabetes, that is, during the pre-diabetic period when insulin levels are markedly increased. In pre-diabetes, microvascular dysfunction correlates with plasma insulin levels and not blood glucose. Here we discuss the concept that insulin, at levels found in pre-diabetes, contributes to microvascular disease in skeletal muscle by inhibiting the release of the vasodilator, adenosine triphosphate (ATP), from erythrocytes.