Callosal dysfunction in amyotrophic lateral sclerosis correlates with diffusion tensor imaging of the central motor system
Callosal dysfunction in amyotrophic lateral sclerosis correlates with diffusion tensor imaging of the central motor system
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DOI：
10.1016/j.nmd.2008.02.005
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发表时间：
2008-05-01
影响因子：
2.8
通讯作者：
Ehrenreich, Hannelore
中科院分区：
文献类型：
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作者：
Bartels, Claudia;Mertens, Nina;Ehrenreich, Hannelore
我们研究了在关节萎缩性侧索硬化症(ALS)中胼胝体退行性变的频率和功能相关性。共有22名肌萎缩侧索硬化症患者和29名健康对照进行了新开发的对侧联合运动测试，以此作为衡量膝盖骨功能障碍的指标。应用弥散张量成像技术测定每组13例受试者的运动纤维交叉部位和锥体束的各向异性分数。ALS患者的联合运动量是健康受试者的两倍多。对侧同向运动与胼胝体运动区的各向异性分数相关，ALS功能评分作为疾病进展的衡量标准也是如此。在两组患者中，对侧同向运动与中枢运动指数(锥体束和结缔组织运动区各向异性分数平均值之比)相关。神经心理学测试结果未能显示出与功能或形态参数的相关性。结合对侧共运动试验和扩散张量成像，ALS患者退行性中枢运动神经元网络的功能和形态损害之间存在密切关系。对侧共运动试验为未来的神经保护试验提供了独立于ALS功能分级的简单症状量化手段。(C)2008爱思唯尔B.V.保留所有权利。
We investigated the frequency and functional relevance of corpus callosum degeneration in arnyotrophic lateral sclerosis (ALS). A total of 22 ALS patients and 29 healthy controls performed the newly developed Contralateral Co-Movement Test as indicator of callosal dysfunction. Diffusion tensor imaging was applied to determine fractional anisotropy values in the callosal area containing the crossing motor fibers and in the pyramidal tracts in 13 subjects of each group.ALS patients had more than twice the amount of co-movements as compared to healthy subjects. Contralateral co-movements correlated with fractional anisotropy values of the corpus callosum motor region as did ALS Functional Rating Scale as measure of disease progression. In both groups, contralateral co-movements correlated with the central motor index (ratio of the mean of fractional anisotropy values of both pyramidal tracts and corpus callosum motor region). Neuropsychological test results failed to show correlations with functional or morphological parameters.Combining Contralateral Co-Movement Test and diffusion tensor imaging in ALS revealed the close relation between functional and morphological impairment in the degenerating central motor-neuronal network. The Contralateral Co-Movement Test delivers simple means of symptom quantification, independent of ALS Functional Rating Scale, for future neuroprotective trials. (c) 2008 Elsevier B.V. All rights reserved.