Teratogenic potential of cocaine hydrochloride in CF-1 mice.
Teratogenic potential of cocaine hydrochloride in CF-1 mice.
复制标题
盐酸可卡因对 CF-1 小鼠的致畸潜力。
DOI：
10.1002/jps.2600690625
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发表时间：
1980
影响因子：
3.8
通讯作者：
David E. Mann
中科院分区：
文献类型：
--
作者：
M. P. Mahalik;R. Gautieri;David E. Mann
本研究显示，在妊娠第7-12天以无毒剂量给予CF-1妊娠小鼠时，盐酸可卡因具有致畸性。CF-1小鼠胎儿对盐酸可卡因的致畸易感性在整个妊娠期都很明显。古柯碱刺激后妊娠早期出现的眼部缺损和后期出现的骨骼缺损与个体发生的顺序是一致的。
This investigation revealed that cocaine hydrochloride was teratogenic when administered in nontoxic doses to gravid CF-1 mice on Days 7-12 of gestation. The teratogenic susceptibility of the CF-1 mouse fetus to cocaine hydrochloride was evident throughout this portion of the gestation period. The early appearance of eye defects and the occurrence of skeletal defects later in gestation after cocaine hydrochloride challenge paralleled the sequence of ontogenesis.