Depression of neutrophil function induced by viruses and its role in secondary microbial infections.
Depression of neutrophil function induced by viruses and its role in secondary microbial infections.
复制标题
病毒引起的中性粒细胞功能抑制及其在继发性微生物感染中的作用。
DOI：
10.1093/clinids/10.2.326
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Mills,EL
中科院分区：
文献类型：
--
作者：
Abramson,JS;Mills,EL
大量证据表明，病毒可使动物和人类宿主易患继发性局部和全身性细菌和真菌疾病。病毒引起这些重复感染的机制涉及病毒对感染部位组织的直接影响和参与免疫监视的细胞的改变。病毒对淋巴细胞、单核细胞和巨噬细胞的影响最近已被审查。许多病毒已被证明可以抑制多形核白细胞的各种功能，而这些功能对于控制细菌和真菌感染至关重要。由不同病毒引起的多形核白细胞功能的改变包括粘附、趋化、吞噬、氧化、分泌和杀菌活性的异常。各种病毒对中性粒细胞的影响和病毒诱导的中性粒细胞功能障碍在诱发宿主继发感染中的作用进行了综述。
A large body of evidence has accumulated indicating that viruses can predispose animal and human hosts to secondary local and systemic bacterial and fungal disease. The mechanism by which viruses cause these superinfections involves both a direct effect of viruses on the tissues at the site of infection and alterations in cells involved in immune surveillance. The effect of viruses on lymphocytes, monocytes, and macrophages has recently been reviewed. A number of viruses have been shown to depress various functions of polymorphonuclear leukocytes, which are critical for controlling bacterial and fungal infections. The alterations in functions of polymorphonuclear leukocytes induced by different viruses include abnormalities of adherence, chemotaxis, phagocytic, oxidative, secretory, and bactericidal activities. The effect of various viruses on neutrophils and the role that virus-induced neutrophil dysfunction has in predisposing the host to secondary infections are reviewed.