Evaluating spatial disparities of rotor sites and high dominant frequency regions during catheter ablation for PersAF patients targeting high dominant frequency sites using non-contacting mapping.
Evaluating spatial disparities of rotor sites and high dominant frequency regions during catheter ablation for PersAF patients targeting high dominant frequency sites using non-contacting mapping.
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DOI：
10.3389/fphys.2022.946718
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发表时间：
2022
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
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目的：一些研究强调了高主频（HDF）和转子在AF永久化中的重要性。然而，这两个属性之间的共定位关系尚未完全理解。在这项研究中，我们的目的是评估HDF区域和转子部位的空间分布在左心房（LA）的HDF引导消融术前和后的房颤。 方法：本研究涉及10例接受靶向左心房HDF区域导管消融术的房颤患者。2048-使用非接触式阵列（EnSite，Abbott）在消融前后收集心房电图（AEG）通道。将2048个点中DF在最大值的0.25 Hz范围内的主频率（DF，4-10 Hz）区域定义为“高”DF（HDF）。转子被定义为持续时间超过100 ms并且在后续相位帧中随时间推移处于相似位置的PS。 结果如下：结果表明，对于非终止消融病例，消融前与消融后HDF区域和转子部位之间的空间相关性极差（消融前：CORR; 0.05 ± 0.17。对比术后：CORR; −0.030 ± 0.19，以及终止患者（术前：CORR; −0.016 ± 0.03。post：CORR; −0.022 ± 0.04）。与AF终止相关的转子在消融后具有较长的寿命（未终止vs.终止120.7 ± 6.5 ms vs. 139.9 ± 39.8 ms）、高核心速度（1.35 ± 1.3 mm/ms vs. 1.32 ± 0.9 mm/ms）和较少弯曲（3.4 ± 3.04 mm vs. 1.5± 1.2 mm）。尽管结果表明终止和未终止患者中转子部位和AFCL变化部位之间的空间重叠较差，但在终止患者中确定了较高的相关性（空间重叠百分比分别为：术前25 ± 4.2% vs. 17 ± 3.8% vs.术后8 ± 4.2% vs. 3.7 ± 1.7% p < 0.05）。 结论：使用非接触式AEG发现，HDF区域的空间分布与转子位置之间的相关性较差。消融后房颤终止的患者转子持续时间更长，速度更快，更稳定。转子部位与导致AF终止的AFCL变化部位的空间重叠性较差。
Purpose: Several studies have emphasised the significance of high dominant frequency (HDF) and rotors in the perpetuation of AF. However, the co-localisation relationship between both attributes is not completely understood yet. In this study, we aim to evaluate the spatial distributions of HDF regions and rotor sites within the left atrium (LA) pre and post HDF-guided ablation in PersAF. Methods: This study involved 10 PersAF patients undergoing catheter ablation targeting HDF regions in the LA. 2048-channels of atrial electrograms (AEG) were collected pre- and post-ablation using a non-contact array (EnSite, Abbott). The dominant frequency (DF, 4–10 Hz) areas with DF within 0.25 Hz of the maximum out of the 2048 points were defined as “high” DF (HDF). Rotors were defined as PSs that last more than 100 ms and at a similar location through subsequent phase frames over time. Results: The results indicated an extremely poor spatial correlation between the HDF regions and sites of the rotors in pre-versus post-ablation cases for the non-terminated (pre: CORR; 0.05 ± 0.17. vs. post: CORR; −0.030 ± 0.19, and with terminated patients (pre: CORR; −0.016 ± 0.03. post: CORR; −0.022 ± 0.04). Rotors associated with AF terminations had a long-lasting life-span post-ablation (non-terminated vs. terminated 120.7 ± 6.5 ms vs. 139.9 ± 39.8 ms), high core velocity (1.35 ± 1.3 mm/ms vs. 1.32 ± 0.9 mm/ms), and were less meandering (3.4 ± 3.04 mm vs. 1.5 ± 1.2 mm). Although the results suggest a poor spatial overlapping between rotors’ sites and sites of AFCL changes in terminated and non-terminated patients, a higher correlation was determined in terminated patients (spatial overlapping percentage pre: 25 ± 4.2% vs. 17 ± 3.8% vs. post: 8 ± 4.2% vs. 3.7 ± 1.7% p < 0.05, respectively). Conclusion: Using non-contact AEG, it was noted that the correlation is poor between the spatial distribution of HDF regions and sites of rotors. Rotors were longer-lasting, faster and more stationary in patients with AF termination post-ablation. Rotors sites demonstrated poor spatial overlapping with sites of AFCL changes that lead to AF termination.
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影响因子：
24
作者：
Earley, Mark J.;Abrams, Dominic J. R.;Schilling, Richard J.
通讯作者：
Schilling, Richard J.
影响因子：
20.1
作者：
Ashihara T;Haraguchi R;Nakazawa K;Namba T;Ikeda T;Nakazawa Y;Ozawa T;Ito M;Horie M;Trayanova NA
通讯作者：
Trayanova NA
影响因子：
24
作者：
Lemola, Kristina;Ting, Michael;Oral, Hakan
通讯作者：
Oral, Hakan
影响因子：
7
作者：
Honarbakhsh, Shohreh;Schilling, Richard J.;Hunter, Ross J.
通讯作者：
Hunter, Ross J.
影响因子：
37.8
作者：
Haïssaguerre, M;Sanders, P;Jaïs, P
通讯作者：
Jaïs, P