Distribution of sensorin immunoreactivity in the central nervous system of Helix pomatia:: Functional aspects
Distribution of sensorin immunoreactivity in the central nervous system of Helix pomatia:: Functional aspects
复制标题
DOI：
10.1002/jnr.10841
复制
发表时间：
2004-01-01
影响因子：
4.2
通讯作者：
Ghirardi, M
中科院分区：
文献类型：
--
作者：
Casadio, A;Fiumara, F;Ghirardi, M
螺旋属的蜗牛通常被用来研究细胞水平上的一些行为及其可塑性。由于对这些物种的感觉神经元的认识还很不完整，我们研究了在双鱼中枢神经系统中存在和分布的对机械感觉神经元特异性肽sensorin的免疫反应性。我们发现，除了脚神经节外，大多数免疫阳性细胞聚集在所有中央神经节中，只有一个大神经元被染色。脑神经节内对称的染色细胞簇与海兔的脑J细胞簇具有同源性。这些螺旋状大脑簇的大部分体细胞将轴突发送到同侧脑侧结缔组织神经和唇神经，并与位于内侧相邻簇的细胞建立单突触连接。这种单突触回路可以在培养中重建，在那里它显示同突触抑制，就像在神经节准备中一样。(C) 2003 Wiley-Liss, Inc。
Land snails belonging to the genus Helix are commonly used to study several behaviors and their plasticity at the cellular level. Because the knowledge of sensory neurons in these species is far from being complete, we have investigated the presence and distribution in Helix pomatia central nervous system of the immunoreactivity for sensorin, a peptide specific for mechanosensory neurons in Aplysia. We found that the majority of immunopositive cells were grouped in clusters located in all the central ganglia, except for the pedal ganglion, where only a single large neuron was stained. A symmetrical cluster of stained cells in the cerebral ganglia showed homology with the cerebral J clusters in Aplysia. Most of the somata of these Helix cerebral clusters send their axons in the ipsilateral cerebropeclal connective and lip nerves and make monosynaptic connections with cells located in a medial adjacent cluster. This monosynaptic circuit can be reestablished in culture, where it shows homosynaptic depression as it does in the ganglionic preparation. (C) 2003 Wiley-Liss, Inc.