On the correlation between the water diffusion coefficient and oxygen tension in RIF-1 tumors
On the correlation between the water diffusion coefficient and oxygen tension in RIF-1 tumors
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DOI：
10.1002/(sici)1099-1492(199805)11:3
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发表时间：
1998-05-01
影响因子：
2.9
通讯作者：
Sotak, CH
中科院分区：
文献类型：
--
作者：
Helmer, KG;Han, S;Sotak, CH
水扩散系数图谱与隔离全氟化碳 (PFC) 乳剂的 (19)F 反转恢复回波平面成像 (IR-EPI) 结合使用，研究辐射诱导纤维肉瘤 (RIF-1) 肿瘤中水扩散系数与组织氧分压 (pO(2)) 之间的空间相关性（n = 11）。与扩散时间相关的表观扩散系数 D(t) 通过获取 20 个不同扩散时间的扩散系数图来确定。选择D(t)曲线不同区域的四个代表性时间点的图进行最终分析。静脉注射的 PFC 乳剂全氟 15 冠 5 醚用于生成 pO(2) 图。 D(t) 和 pO(2) 数据是通过动物呼吸空气或卡波金 (95% O(2) - 5% CO(2)）获得的，以研究肿瘤 pO(2) 增加对 D(t) 的影响。当呼吸气体从空气改为卡波金时，肿瘤 pO(2) 平均增加 22 托。从 D(t)（空气呼吸）与 D(t)（卡波根呼吸）的像素数据生成的相关图显示与统一斜率几乎没有偏差。 D(t) 与 PO(2) 的相关图表明这两个参数之间不存在相关性。这项研究还证实，根据长扩散时间的 D(t) 图，可以最好地将坏死组织与活肿瘤组织区分开来。 (C) 1998 约翰威利父子有限公司
Water diffusion-coefficient mapping was used in conjunction with (19)F inversion-recovery echo-planar imaging (IR-EPI) of a sequestered perfluorocarbon (PFC) emulsion to investigate the spatial correlation between the diffusion coefficient of water and the tissue oxygen tension (pO(2)) in radiation-induced fibrosarcoma (RIF-1) tumors (n = 11). The diffusion-time-dependent apparent diffusion coefficient, D(t), was determined by acquiring diffusion coefficient maps at 20 different diffusion times. Maps at four representative time points in different regions of the D(t) curve were selected for final analysis. An intravenously administered PFC emulsion, perfluoro-15-crown-5-ether, was used to generate the pO(2) maps. D(t) and pO(2) data were acquired with the animal breathing either air or carbogen (95% O(2) - 5% CO(2)) to investigate the effects of increased tumor pO(2) on D(t). The average increase in tumor pO(2) was 22 torr when the breathing gas was changed from air to carbogen. Correlation plots generated from pixel data for D(t) (air breathing) vs D(t) (carbogen breathing) show little deviation from a slope of unity. Correlation plots of D(t) vs PO(2) indicate that no correlation is present between these two parameters. This study also confirmed that necrotic tissue was best differentiated from viable tumor tissue based on D(t) maps at long diffusion times. (C) 1998 John Wiley & Sons, Ltd.