Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms
Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms
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MicroRNA-200c-141 簇在各种人类实体恶性肿瘤中的预后作用
DOI：
10.1155/2015/935626
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Xiao Tao
中科院分区：
文献类型：
--
作者：
Li Xiao-yang;Li Hui;Bu Jie;Xiong Liang;Guo Hong-bin;Liu Li-hong;Xiao Tao
miR-200家族最近成为预测癌症预后和肿瘤进展的显着标志物。我们的目的是审查miR-200 c-141基因组簇作为癌症预后生物标志物的证据。结果表明，高水平的miR-200 c对OS（HR = 1.14 [0.77-1.69]，P = 0.501）和DFS/PFS（HR = 0.72 [0.45-1.14]，P = 0.161）无显著影响。分层分析显示，血清/血浆中miR-200 c高表达与OS差显著相关（HR = 2.12 [1.62-2.77]，P = 0.000），但组织中无相关性（HR = 0.89 [0.58-1.37]，P = 0.599）。miR-200 c高表达与组织中有利的DFS/PFS显著相关（HR = 0.56 [0.43-0.73]，P = 0.000），但与血清/血浆中较差的DFS/PFS显著相关（HR = 1.90 [1.08-3.36]，P = 0.027）。对于miR-141，我们发现miR-141高表达对OS无显著影响（HR = 1.18 [0.74-1.88]，P = 0.482），但DFS/PFS较差（HR = 1.11 [1.04-1.20]，P = 0.003）。同样，亚组分析显示，miR-141高表达预测血清/血浆中OS较差（HR = 4.34 [2.30-8.21]，P = 0.000），但组织中OS不佳（HR = 1.00 [0.92-1.09]，P = 0.093）。miR-141高表达与组织中DFS/PFS恶化显著相关（HR = 1.12 [1.04-1.20]，P = 0.002），但与血清/血浆中无相关性（HR = 0.90 [0.44-1.83]，P = 0.771）。我们的研究结果表明，与其组织对应物相比，外周血中miR-200 c和miR-141的表达水平可能更有效地监测癌症预后。高miR-141表达在预测恶性肿瘤的进展方面比生存方面更好。
The miR-200 family has emerged recently as a noticeable marker for predicting cancer prognosis and tumor progression. We aimed to review the evidence of miR-200c-141 genomic cluster as prognostic biomarkers in cancers. The results suggested that high level of miR-200c had no significant impact on OS (HR = 1.14 [0.77–1.69], P = 0.501) and DFS/PFS (HR = 0.72 [0.45–1.14], P = 0.161). Stratified analyses revealed that high miR-200c expression was significantly related to poor OS in serum/plasma (HR = 2.12 [1.62–2.77], P = 0.000) but not in tissues (HR = 0.89 [0.58–1.37], P = 0.599). High miR-200c expression was significantly associated with favorable DFS/PFS in tissues (HR = 0.56 [0.43–0.73], P = 0.000) but worse DFS/PFS in serum/plasma (HR = 1.90 [1.08–3.36], P = 0.027). For miR-141, we found that high miR-141 expression predicted no significant impact on OS (HR = 1.18 [0.74–1.88], P = 0.482) but poor DFS/PFS (HR = 1.11 [1.04–1.20], P = 0.003). Similarly, subgroup analyses showed that high miR-141 expression predicted poor OS in serum/plasma (HR = 4.34 [2.30–8.21], P = 0.000) but not in tissues (HR = 1.00 [0.92–1.09], P = 0.093). High miR-141 expression was significantly associated with worse DFS/PFS in tissues (HR = 1.12 [1.04–1.20], P = 0.002) but not in serum/plasma (HR = 0.90 [0.44–1.83], P = 0.771). Our findings indicated that, compared to their tissue counterparts, the expression level of miR-200c and miR-141 in peripheral blood may be more effective for monitoring cancer prognosis. High miR-141 expression was better at predicting tumor progression than survival for malignant tumors.
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影响因子：
8.8
作者：
Silva-Santos, R. M.;Costa-Pinheiro, P.;Luis, A.;Antunes, L.;Lobo, F.;Oliveira, J.;Henrique, R.;Jeronimo, C.
通讯作者：
Jeronimo, C.
DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
--
作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
通讯作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
影响因子：
8.8
作者：
Lin, H-M;Castillo, L.;Mahon, K. L.;Chiam, K.;Lee, B. Y.;Nguyen, Q.;Boyer, M. J.;Stockler, M. R.;Pavlakis, N.;Marx, G.;Mallesara, G.;Gurney, H.;Clark, S. J.;Swarbrick, A.;Daly, R. J.;Horvath, L. G.
通讯作者：
Horvath, L. G.
DOI：
10.1016/0021-9681(79)90031-6
发表时间：
1979
期刊：
Journal of Chronic Diseases
影响因子：
--
作者：
R. Horwitz
通讯作者：
R. Horwitz
影响因子：
3.7
作者：
Tejero R;Navarro A;Campayo M;Viñolas N;Marrades RM;Cordeiro A;Ruíz-Martínez M;Santasusagna S;Molins L;Ramirez J;Monzó M
通讯作者：
Monzó M