Chemical carcinogenesis: the liver as a model.
Chemical carcinogenesis: the liver as a model.
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化学致癌作用：以肝脏为模型。
DOI：
10.1159/000157000
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Sarma,DS
中科院分区：
文献类型：
--
作者：
Farber,E;Sarma,DS
肝细胞癌（'hepatocellular carcinoma'; LCC）是世界范围内最常见的癌症之一，涉及数百万人，在世界上排名第二。与前10名中的大多数其他癌症不同，它在西方世界（包括美国和加拿大）非常罕见。流行病学上，全世界B型肝炎病毒（HBV）感染（尤其是携带状态）与肝细胞癌的发病率之间存在良好（但并非完美）相关性[2，3]。然而，也有越来越多的证据表明，在中国和非洲的部分地区，至少有一个额外的因素，暴露于真菌毒素。可能在肝癌的病因和/或发病机制中起重要作用[4]，
Liver cell cancer (‘hepatocellular carcino ma’; LCC) is one of the commonest cancers world-wide, involving millions of people and ranking 2nd in the world. Unlike most of the other cancers in the top 10 [1], it is quite uncommon in the Western world including the USA and Canada. Epidemiologically, there is a good (but not a perfect) correlation between the incidence of hepatitis B virus (HBV) infections, espe cially carrier states, and of liver cell cancer the world over [2, 3]. However, there is also increasing evidence that in some locations such as parts of China and Africa, at least one additional factor, exposure to mycotoxins. may play an important role in the etiology and/or pathogenesis of liver cancer [4], In the