Autobiographical Memory Specificity in Major Depression Treated With Electroconvulsive Therapy
Autobiographical Memory Specificity in Major Depression Treated With Electroconvulsive Therapy
复制标题
电休克疗法治疗重度抑郁症的自传体记忆特异性
DOI：
10.1097/yct.0000000000000267
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
D. McLoughlin
中科院分区：
文献类型：
--
作者：
A. Jelovac;Stephanie O'Connor;S. McCarron;D. McLoughlin
目的 重度抑郁症的自传体记忆的特点是特异性降低，这反映了总结事件类别的倾向，而不是回忆某个时间和地点的事件的具体实例。这种广泛研究的抑郁症认知标志物尚未在接受电休克治疗 (ECT) 治疗的患者中进行广泛检查。方法 我们对因重度抑郁发作而接受短脉冲为主的双颞叶 ECT 疗程的自然主义患者队列进行了回顾性图表审查。作为常规临床实践的一部分，患者在 ECT 前基线、治疗疗程结束和 3 个月随访时完成了 Kopelman 自传体记忆访谈 (AMI) 的近期生活部分。使用 24 项汉密尔顿抑郁量表评估情绪。结果 我们确定了 48 名符合纳入标准的患者（平均年龄 61.6 岁；女性，62.5%）。总共 77.1% 的患者对 ECT 疗程有反应，29.7% 随后复发。随着时间的推移，AMI 总分或语义和情景分量表没有显着变化。然而，与正常样本相比，患者在所有 3 个评估点的情景自传记忆均明显受损，而个人语义记忆回忆则正常。基线时情景自传记忆的特异性并不能预测对 ECT 的反应或复发的可能性。结论 我们发现 ECT 之前抑郁症患者的情景自传记忆特异性降低，尽管情绪显着改善，但在长期随访中这种情况持续存在。未检测到逆行性遗忘的发现可能反映了 AMI 近期生命部分缺乏检测 ECT 引起的变化的敏感性。
Objective Autobiographical memory in major depression is characterized by reduced specificity, which reflects the tendency to summarize categories of events rather than recall specific instances of events situated in a time and place. This widely studied cognitive marker for depression has not been extensively examined in patients treated with electroconvulsive therapy (ECT). Methods We conducted a retrospective chart review of a naturalistic cohort of patients receiving a course of brief-pulse predominantly bitemporal ECT for a major depressive episode. Patients completed the recent life section of the Kopelman Autobiographical Memory Interview (AMI) at pre-ECT baseline, end of treatment course, and 3-month follow-up as part of routine clinical practice. Mood was assessed using the 24-item Hamilton Rating Scale for Depression. Results We identified 48 patients (mean age, 61.6; female, 62.5%) meeting inclusion criteria. A total of 77.1% of patients responded to the ECT course, 29.7% subsequently relapsed. There were no significant changes over time on either AMI total score or semantic and episodic subscales. However, patients were markedly impaired on episodic autobiographical memory compared with the normative sample at all 3 assessment points, whereas personal semantic memory recall was normal. Specificity of episodic autobiographical memory at baseline did not predict response to ECT or likelihood of relapse. Conclusions We found reduced specificity of episodic autobiographical memory in depressed patients before ECT, which persisted at long-term follow-up despite significant improvement in mood. The finding of no detectable retrograde amnesia likely reflects lack of sensitivity of the recent life section of the AMI to detect ECT-induced changes.
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影响因子：
--
作者：
Lisanby, SH;Maddox, JH;Sackeim, HA
通讯作者：
Sackeim, HA
影响因子：
--
作者：
Sackeim, Harold A.;Dillingham, Elaine M.;Haskett, Roger F.
通讯作者：
Haskett, Roger F.
ECT 后逆行性遗忘的预测因子。
DOI：
10.1176/ajp.152.7.995
发表时间：
1995
期刊：
The American journal of psychiatry.
影响因子：
--
作者：
Sobin,C;Sackeim,HA;Prudic,J;Devanand,DP;Moody,BJ;McElhiney,MC
通讯作者：
McElhiney,MC
影响因子：
12.8
作者：
Sumner, Jennifer A.
通讯作者：
Sumner, Jennifer A.
影响因子：
--
作者：
Sackeim, HA;Prudic, J;Clark, J
通讯作者：
Clark, J