A Metadata description of the data in "A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.".
A Metadata description of the data in "A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.".
复制标题
“在小鼠，大鼠和人类中2型糖尿病的尿中变化的代谢组比较的数据的元数据描述”。
DOI：
10.1186/1756-0500-4-272
复制
发表时间：
2011-07-29
影响因子：
1.8
通讯作者：
Salek RM
中科院分区：
文献类型：
--
作者：
Griffin JL;Atherton HJ;Steinbeck C;Salek RM
代谢组学是一种快速发展的功能基因组学工具，在生物学和医学的各个领域有着广泛的应用。然而，与转录组学和蛋白质组学不同的是，尽管代谢组学标准倡议组织（MSI）努力开发代谢组学实验的标准化描述，但目前还没有存储数据的中央存储库。在这篇论文中，我们描述了如何将MSI描述应用于一个已发表的数据集，该数据集涉及与II型糖尿病相关的跨物种代谢生物标志物的鉴定。该研究描述了小鼠、大鼠和人类志愿者的尿液样本收集，以及随后通过高分辨率1H NMR光谱获取数据。描述元数据是为了演示如何将MSI描述应用于手稿，光谱也可用于小鼠和大鼠研究，以允许其他人处理数据。本文的目的是激发关于MSI描述是否足以描述与代谢组学实验相关的元数据的讨论，并鼓励其他人将其数据提供给其他研究人员。
Metabolomics is a rapidly developing functional genomic tool that has a wide range of applications in diverse fields in biology and medicine. However, unlike transcriptomics and proteomics there is currently no central repository for the depositing of data despite efforts by the Metabolomics Standard Initiative (MSI) to develop a standardised description of a metabolomic experiment. In this manuscript we describe how the MSI description has been applied to a published dataset involving the identification of cross-species metabolic biomarkers associated with type II diabetes. The study describes sample collection of urine from mice, rats and human volunteers, and the subsequent acquisition of data by high resolution 1H NMR spectroscopy. The metadata is described to demonstrate how the MSI descriptions could be applied in a manuscript and the spectra have also been made available for the mouse and rat studies to allow others to process the data. The intention of this manuscript is to stimulate discussion as to whether the MSI description is sufficient to describe the metadata associated with metabolomic experiments and encourage others to make their data available to other researchers.