Zinc Oxide Particles Induce Activation of the Lysosome–Autophagy System
Zinc Oxide Particles Induce Activation of the Lysosome–Autophagy System
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DOI：
10.1021/acsomega.8b01497
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发表时间：
2019-01
期刊：
影响因子：
4.1
通讯作者：
L. Popp;Laura Segatori
中科院分区：
文献类型：
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作者：
L. Popp;Laura Segatori
基于金属氧化物的材料具有高度通用性，并用于从医疗技术到个人护理产品的各种应用中。美国食品和药物管理局普遍认为氧化锌是安全的，氧化锌（ZnO）已越来越多地用于制药，化妆品，食品和日用化学工业。因此，通过职业过程和消费品暴露于纳米和微米尺寸的ZnO颗粒正在增加，并且已经引起了对与ZnO基材料的大规模生产和商业化相关的健康影响的关注。因此，重要的是要研究ZnO颗粒与生物系统的相互作用，并阐明对细胞生理学的影响。特别令人感兴趣的是对氧化锌颗粒的自噬反应，因为自噬是响应外来物质摄取而激活的第一道防线。溶酶体-自噬系统作为主要的细胞分解代谢途径，在细胞内代谢中起着重要的作用。
Metal-oxide-based materials are highly versatile and used in a wide variety of applications ranging from medical technology to personal care products. Generally recognized as safe by the US Food and Drug Administration, zinc oxide (ZnO) has been increasingly used in pharmaceutical, cosmetic, food, and commodity chemical industries. As a result, exposure to nano- and micron-sized ZnO particles through occupational processes and consumer products is increasing and has raised concerns over the health effects associated with the large-scale production and commercialization of ZnO-based materials. It is therefore important to investigate the interaction of ZnO particles with biological systems and elucidate the consequent effect on cell physiology. Of particular interest is the autophagic response to zinc oxide particles, as autophagy is the first line of defense activated in response to the uptake of foreign materials. As the main cellular catabolic pathway, the lysosome–autophagy system plays an important ho...