Autobiographical memory in non-amnesic alcohol-dependent patients
Autobiographical memory in non-amnesic alcohol-dependent patients
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DOI：
10.1017/s0033291706008798
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发表时间：
2006-12-01
影响因子：
6.9
通讯作者：
Noel, Xavier
中科院分区：
文献类型：
--
作者：
D'Argembeau, Arnaud;Van der Linden, Martial;Noel, Xavier
背景。慢性酒精滥用与广泛的认知缺陷有关。然而，对于非健忘症酒精患者对现实生活事件的记忆（自传式记忆）知之甚少。本研究的目的是调查(a)非健忘症酗酒者回忆特定自传体记忆的能力，以及(h)他们访问特定记忆时的主观体验。20名非失忆症（没有Korsakoff综合征）的戒酒者和20名健康对照者完成了自传式记忆测试（AMT）和记忆特征问卷调查（MCQ），前者评估了在对提示词作出反应时回忆特定记忆（与一般记忆相比）的频率，后者评估了在回忆特定事件时的主观体验（例如所经历的感觉和背景细节的数量）。与健康对照组相比，酗酒患者回忆特定记忆的频率更低，而回忆一般记忆的频率更高。然而，当一个特定的过去事件被访问时，酗酒患者主观上经历了与对照组一样多的感官和背景细节。这些发现表明，非健忘性酗酒者在战略性地获取特定事件的自传体知识方面存在困难，这可能是由于与酒精中毒相关的额叶功能改变所致。
Background. Chronic alcohol abuse is associated with a wide range of cognitive deficits. However, little is known about memory for real-life events (autobiographical memory) in non-amnesic alcoholic patients. The Purpose of this Study was to investigate (a) non-amnesic alcoholics' ability to recall specific autobiographical memories and (h) their subjective experience when they access specific memories.Method. Twenty non-amnesic (without Korsakoff syndrome) recently detoxified alcoholics and 20 healthy controls completed the Autobiographical Memory Test (AMT), which assesses the frequency of specific (versus general) memories recalled in response to cue words, and the Memory Characteristics Questionnaire (MCQ), which assesses subjective experience (e.g. the amount of sensory and contextual details experienced) when remembering specific events.Results. Alcoholic patients recalled specific memories less frequently and general memories more frequently than healthy controls. Nevertheless, when a specific past event was accessed, alcoholic patients Subjectively experienced as many sensory and contextual details as controls.Conclusions. These findings Suggest that non-amnesic alcoholics have difficulties strategically accessing event-specific autobiographical knowledge, which might result from changes in frontal lobe function that are associated with alcoholism..