Low-grade follicular lymphoma with t(14;18) presents a homogeneous disease entity otherwise the rest comprises minor groups of heterogeneous disease entities with Bcl2 amplification, Bcl6 translocation or other gene aberrances
Low-grade follicular lymphoma with t(14;18) presents a homogeneous disease entity otherwise the rest comprises minor groups of heterogeneous disease entities with Bcl2 amplification, Bcl6 translocation or other gene aberrances
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DOI：
10.1038/sj.leu.2403738
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发表时间：
2005-06-01
期刊：
影响因子：
11.4
通讯作者：
Ohshima, K
中科院分区：
文献类型：
--
作者：
Guo, Y;Karube, K;Ohshima, K
滤泡性淋巴瘤（FL）被世界卫生组织在形态学上分为1级、2级、3a级和3b级。Bcl 2、Bcl 6和CD 10是FL的表型标记，而Bcl 2 t（14;18）和Bcl 6 t（3q 27）基因易位是FL常见的遗传改变。然而，迄今为止，还没有综合分析的基础上表型，级别和基因型从大量的FL病例。我们对261例FL进行了分级，并确定了其表型和基因改变。根据147例FL的抗原标志和基因改变，将FL分为典型型和其他型。典型组（69%）表现为组织学分级低（1、2级）、Bcl 2和CD 10共表达及Bcl 2基因易位。其余包括一小部分无Bcl 2基因易位的低度FL和高度FL（3a、3b级），这些FL包括一些异质性疾病实体。病理分级高（87%），无明确的BCL 2或CD 10表达，有多种基因异常，包括Bcl 2易位、Bcl 6易位、Bcl 2扩增或其他未知基因异常。我们的研究结果表明，典型的FL提出了一个同质的疾病实体，而其余包括异质性疾病实体。
Follicular lymphomas (FL) are morphologically classified into grades 1, 2, 3a and 3b by the World Health Organization. Bcl2, Bcl6 and CD10 are phenotypic markers of FL while the Bcl2 t(14;18) and Bcl6 t(3q27) gene translocations are common genetic changes. However, to date, there has been no integrated analysis based on phenotype, grade and genotype from large numbers of FL cases. We graded 261 cases of FL and determined their phenotypes and gene alterations. According to the antigen markers and gene alterations of 147 cases, we classified FL into typical and the others types. The typical group, which includes 69% cases of FL, is characterized by low histological grade ( grade 1, 2), coexpression of BCL2 and CD10 and Bcl2 gene translocation. The rest comprises a small part of low-grade FL without Bcl2 gene translocation and high-grade (grade 3a, 3b) FL. These FLs include some heterogeneous disease entities. They are characterized by high histological grade (87%), no definite expression of BCL2 or CD10 and several kinds of gene aberrances including Bcl2 translocation, Bcl6 translocation, Bcl2 amplification or other unknown gene abnormality. Our findings indicate that typical FL presents a homogeneous disease entity whereas the rest comprises heterogeneous diseases entities.