Developmental expression of the CaM kinase II isoforms:: ubiquitous γ- and δ-CaM kinase II are the early isoforms and most abundant in the developing nervous system
Developmental expression of the CaM kinase II isoforms:: ubiquitous γ- and δ-CaM kinase II are the early isoforms and most abundant in the developing nervous system
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DOI：
10.1016/s0169-328x(99)00131-x
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发表时间：
1999-06-18
期刊：
影响因子：
--
通讯作者：
Harbers, K
中科院分区：
文献类型：
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作者：
Bayer, KU;Löhler, J;Harbers, K
CaM激酶II是一个多功能蛋白激酶家族，在Ca2+介导的信号转导中发挥重要作用。作为了解它们在小鼠发育中可能的功能的第一步，我们表征了从产前发育开始的所有CaM激酶II同种型（α，β，γ和δ）的表达模式。值得注意的是，只有普遍存在的γ-和δ-CaM激酶II在早期发育过程中表达。它们的分布表明在发育中的神经系统和成熟的可兴奋组织中的特殊作用。此外，我们描述了鼠β（M）-钙调素激酶II，一种变异的'脑特异性' β-钙调素激酶II，这是高度表达的骨骼肌。(C)1999 Elsevier Science B.V.保留所有权利。
CaM kinase II constitutes a family of multifunctional protein kinases that play a major role in Ca2+-mediated signal transduction. As a first step in understanding their possible function in mouse development we characterized the expression patterns of all CaM kinase II isoforms (alpha, beta, gamma and delta) starting in prenatal development. Remarkably, only the ubiquitous gamma- and delta-CaM kinase II are expressed during early development. Their distribution suggests a special role in the developing nervous system and in mature excitable tissues. Additionally, we describe the murine beta(M)-CaM kinase II, a variant of the 'brain-specific' beta-CaM kinase II, which is highly expressed in skeletal muscle. (C) 1999 Elsevier Science B.V. All rights reserved.