Growth rate of small lung cancers detected on mass CT screening
Growth rate of small lung cancers detected on mass CT screening
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DOI：
10.1259/bjr.73.876.11205667
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发表时间：
2000-12-01
影响因子：
2.6
通讯作者：
Watanabe, T
中科院分区：
文献类型：
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作者：
Hasegawa, M;Sone, S;Watanabe, T
CT 最近已用于肺癌的大规模筛查。已经发现了小癌症，但这些病变的生长特征尚未完全了解。我们在为期 3 年的大规模 CT 筛查计划中发现了 82 种原发性癌症，其中 61 种在本研究中进行了检查。使用连续年度 CT 图像或后续 CT 图像基于指数模型计算体积倍增时间 (VDT)。所有病例均在医院接受高分辨率CT（HRCT）检查。根据HRCT特征将病变分为三型：G型（n=19）、毛玻璃样混浊（GGO）； GS 型 (n=19)，具有实心中心成分的局灶性 GGO； S 型（n=23），实性结节。常规胸片上看不到 G 型病灶 18 个（95%）、GS 型病灶 18 个（95%）和 S 型病灶 7 个（30%）。 G型、GS型和S型的肿瘤平均大小分别为10mm、11mm和16mm。大多数肿瘤（80%）是腺癌；其中 78% 是 GGO（G 型和 GS 型）。 G型、GS型和S型的平均VDT值分别为813天、457天和149天；它们彼此显着不同（p
CT has recently been used in mass screening for lung cancer. Small cancers have been identified but the growth characteristics of these lesions are not fully understood. We identified 82 primary cancers in our 3-year mass CT screening programme, of which 61 were examined in the present study. The volume doubling time (VDT) was calculated based on the exponential model using successive annual CT images or follow-up CT images. All cases were also examined in the hospital by high resolution CT (HRCT). Lesions were divided into three types based on HRCT characteristics: type G (n=19), ground glass opacity (GGO); type GS (n=19), focal GGO with a solid central component; and type S (n=23), solid nodule. 18 (95%) lesions of type G, 18 (95%) of type GS and 7 (30%) of type S were invisible on conventional chest radiographs. The mean size of the tumour was 10 mm, 11 mm and 16 mm for type G, type GS and type S, respectively. Most tumours (80%) were adenocarcinomas; 78% of these were GGO (type G and GS). Mean VDT values were 813 days, 457 days and 149 days for type G, type GS and type S, respectively; these are significantly different from each other (p