Hostility and physiological responses to acute stress in people with type 2 diabetes.
Hostility and physiological responses to acute stress in people with type 2 diabetes.
复制标题
DOI：
10.1097/psy.0000000000000172
复制
发表时间：
2015-05
影响因子：
3.3
通讯作者：
Steptoe A
中科院分区：
文献类型：
--
作者：
Hackett RA;Lazzarino AI;Carvalho LA;Hamer M;Steptoe A
敌意与心血管死亡率和发病率有关，其机制之一可能涉及对精神压力的高度反应。然而，针对心血管疾病高危人群的研究却很少。本研究的目的是评估 2 型糖尿病患者的敌意与急性应激反应之间的关系。共有 140 名 2 型糖尿病患者（中位年龄 [标准差] 63.71 [7.00] 岁）参加了基于实验室的实验压力测试。在基线、两次应激任务期间以及 45 分钟和 75 分钟后评估收缩压、舒张压、心率、血浆白细胞介素 6 (IL-6) 和唾液皮质醇。使用库克混合愤世嫉俗敌意量表评估愤世嫉俗的敌意。敌意得分较高的参与者因急性应激任务而导致 IL-6 水平升高 (B = 0.082，p = .002)，与年龄、性别、体重指数、吸烟、家庭收入、测试时间、药物治疗和基线 IL-6 无关。敌意与应激后皮质醇输出呈负相关（B = -0.017，p = .002），与协变量无关。没有观察到敌意与血压或心率反应之间存在关联。患有 2 型糖尿病的敌对个体可能容易受到压力引起的炎症增加的影响。需要进一步的研究来了解这些变化是否会增加该人群患心血管疾病的风险。
Hostility is associated with cardiovascular mortality and morbidity, and one of the mechanisms may involve heightened reactivity to mental stress. However, little research has been conducted in populations at high risk for cardiovascular disease. The aim of the present study was to assess the relationship between hostility and acute stress responsivity in individuals with Type 2 diabetes. A total of 140 individuals (median age [standard deviation] 63.71 [7.00] years) with Type 2 diabetes took part in laboratory-based experimental stress testing. Systolic blood pressure, diastolic blood pressure, heart rate, plasma interleukin-6 (IL-6), and salivary cortisol were assessed at baseline, during two stress tasks, and 45 and 75 minutes later. Cynical hostility was assessed using the Cook Medley Cynical Hostility Scale. Participants with greater hostility scores had heightened increases in IL-6 induced by the acute stress tasks (B = 0.082, p = .002), independent of age, sex, body mass index, smoking, household income, time of testing, medication, and baseline IL-6. Hostility was inversely associated with cortisol output poststress (B = −0.017, p = .002), independent of covariates. No associations between hostility and blood pressure or heart rate responses were observed. Hostile individuals with Type 2 diabetes may be susceptible to stress-induced increases in inflammation. Further research is needed to understand if such changes increase the risk of cardiovascular disease in this population.