Complex neural representation of odour information in the olfactory bulb.
Complex neural representation of odour information in the olfactory bulb.
复制标题
嗅球中气味信息的复杂神经表征
DOI：
10.1111/apha.13333
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Restrepo D
中科院分区：
文献类型：
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作者：
Li A;Rao X;Zhou Y;Restrepo D
嗅觉系统最重要的任务是在不同的大脑和行为状态下产生对气味信息的精确表征。嗅球作为嗅觉系统的第一个加工阶段和关键枢纽，在气味的神经表征中起着关键作用，编码气味的身份，强度和时间。虽然嗅球用于气味表征的神经回路和编码策略最初是在麻醉动物中确定的，但最近大量的研究集中在清醒行为动物嗅球中气味的神经表征上。本文就这些研究成果进行综述，包括：（1）嗅球内气味表征的神经回路以及嗅球与高级加工中心之间的功能联系;（2）嗅闻等相关因素如何影响和塑造气味表征;（3）不同状态下气味表征的变化;以及（4）清醒行为中气味呈现时间方面处理的最新进展。我们强调讨论当前的观点和新兴的建议在嗅球的气味的神经代表。
The most important task of the olfactory system is to generate a precise representation of odor information under different brain and behavioral states. As the first processing stage in the olfactory system and a crucial hub, the olfactory bulb plays a key role in the neural representation of odors, encoding odor identity, intensity, and timing. Although the neural circuits and coding strategies used by the olfactory bulb for odor representation were initially identified in anesthetized animals, a large number of recent studies focused on neural representation of odorants in the olfactory bulb in awake behaving animals. In this review, we discuss these recent findings, covering (1) the neural circuits for odor representation both within the olfactory bulb and functional connections between the olfactory bulb and higher order processing centers; (2) how related factors such as sniffing affect and shape the representation; (3) how the representation changes under different states; and (4) recent progress on the processing of temporal aspects of odor presentation in awake, behaving. We highlight discussion of the current views and emerging proposals on the neural representation of odorants in the olfactory bulb.