PROTEINS WITH LEUCINE-RICH REPEATS
PROTEINS WITH LEUCINE-RICH REPEATS
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DOI：
10.1016/0959-440x(95)80105-7
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发表时间：
1995-06-01
影响因子：
6.8
通讯作者：
DEISENHOFER, J
中科院分区：
文献类型：
--
作者：
KOBE, B;DEISENHOFER, J
富含亮氨酸的重复序列是存在于六十多种蛋白质中的短序列基序，所有这些似乎都参与蛋白质-蛋白质相互作用。核糖核酸酶抑制剂的晶体结构表明重复序列对应于β-α结构单元。最近确定的核糖核酸酶A-核糖核酸酶抑制剂复合物的晶体结构表明富含亮氨酸的重复序列的蛋白质结合功能的基础。
Leucine-rich repeats are short sequence motifs present in over sixty proteins, all of which appear to be involved in protein-protein interactions. The crystal structure of ribonuclease inhibitor demonstrated that the repeats correspond to beta-alpha structural units. The recently determined crystal structure of the ribonuclease A-ribonuclease inhibitor complex suggests the basis for the protein-binding function of leucine-rich repeats.