Senescence in immune priming and attractiveness in a beetle
Senescence in immune priming and attractiveness in a beetle
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DOI：
10.1111/j.1420-9101.2012.02516.x
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发表时间：
2012-07-01
影响因子：
2.1
通讯作者：
Krams, I.
中科院分区：
文献类型：
--
作者：
Daukste, J.;Kivleniece, I.;Krams, I.
与年龄相关的免疫活性下降被称为免疫衰老，已经在脊椎动物的适应性免疫反应和无脊椎动物的先天免疫系统中观察到。由于维持基本水平的免疫防御和建立免疫反应是昂贵的，免疫功能的最佳投资应该在个体状态（如个体年龄）的广泛范围内变化。在这项研究中，我们以粉虫（tenbrio molitor）为模型生物，测试了个体的免疫反应和免疫启动是否会随着年龄的增长而降低。我们还测试了衰老和免疫启动是否会影响男性产生的气味。我们发现，与molitor相似的年轻雄性t .能够在无菌尼龙单丝植入物中产生免疫反应，并有可能通过免疫启动机制表现出一种简单形式的免疫记忆。老年男性对第二次免疫挑战的免疫反应没有增加，这对他们的性吸引力和剩余寿命产生了负面影响。我们的研究结果表明，与molitor相似的老年雄性t .的免疫系统效率较低，这表明衰老、免疫反应和性吸引力之间存在复杂的进化权衡。
Age-related decline in immune activity is referred to as immunosenescence and has been observed for both the adaptive immune response of vertebrates and the innate immune system of invertebrates. Because maintaining a basic level of immune defence and mounting an immune response is costly, optimal investment in immune function should vary over a wide range of individual states such as the individuals age. In this study, we tested whether the immune response and immunological priming within individuals become less efficient with age using mealworm beetles, Tenebrio molitor, as a model organism. We also tested whether ageing and immunological priming affected the odours produced by males. We found that young males of T.similar to molitor were capable of mounting an immune response a sterile nylon monofilament implant with the potential to exhibit a simple form of immune memory through mechanisms of immune priming. Older males did not increase their immune response to a second immune challenge, which negatively affected their sexual attractiveness and remaining life span. Our results indicate that the immune system of older males in T.similar to molitor is less effective, suggesting complex evolutionary trade-offs between ageing, immune response and sexual attractiveness.