Cytonemes:: Cellular processes that project to the principal signaling center in Drosophila imaginal discs
Cytonemes:: Cellular processes that project to the principal signaling center in Drosophila imaginal discs
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DOI：
10.1016/s0092-8674(00)80771-0
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发表时间：
1999-05-28
期刊：
影响因子：
64.5
通讯作者：
Kornberg, TB
中科院分区：
文献类型：
--
作者：
Ramírez-Weber, FA;Kornberg, TB
果蝇的翅盘细胞是通过利用与前/后室边界相关的信号中心接收的信息发育的。我们在这里显示，椎间盘细胞薄，肌动蛋白为基础的扩展（cytonemes）项目，这个信号中心。当来自翅盘的侧腹的细胞与来自A/P边界的细胞相邻或与成纤维细胞生长因子的来源相邻培养时，可以诱导细胞丝。小鼠肢芽细胞在短暂的培养期间也生长出突起，表明细胞丝是脊椎动物和无脊椎动物细胞的属性。我们认为，cytonemes可能是负责某些形式的长距离细胞间通讯。
Wing imaginal disc cells in Drosophila develop by using information received from a signaling center associated with the anterior/posterior compartment border. We show here that disc cells have thin, actin-based extensions (cytonemes) that project to this signaling center. Cytonemes can be induced when cells from the lateral flanks of a wing disc are cultured next to cells from the A/P border or next to a source of fibroblast growth factor. Mouse limb bud cells also grow projections during a brief culture period, indicating that cytonemes are an attribute of both vertebrate and invertebrate cells. We suggest that cytonemes may be responsible for some forms of long-range cell-cell communication.