Efficient synthesis of pyrrolo[1,2-a]quinoxalines catalyzed by a Bronsted acid through cleavage of C-C bonds
Efficient synthesis of pyrrolo[1,2-a]quinoxalines catalyzed by a Bronsted acid through cleavage of C-C bonds
复制标题
布朗斯台德酸催化 C-C 键断裂高效合成吡咯并[1,2-a]喹喔啉
DOI：
10.1039/c6ob01401a
复制
发表时间：
2016
影响因子：
3.2
通讯作者：
Ma Chen
中科院分区：
文献类型：
--
作者：
Xie Caixia;Feng Lei;Li Wanli;Ma Xiaojun;Ma Xinkun;Liu Yihan;Ma Chen
本文报道了一种简便、有效的一锅多米诺反应直接合成吡咯并[1，2-a]喹喔啉的方法。该方法利用了由布朗斯特酸催化的亚胺形成反应、SEAr反应和C-C键的裂解。β-二酮和β-酮基酯都具有良好的耐受性，以中等至优异的产率得到相应的产物。
An efficient and convenient one-pot domino reaction for the direct synthesis of pyrrolo[1,2-a]quinoxalines has been developed. This approach utilizes an imine formation reaction, SEAr reaction and cleavage of C–C bonds catalyzed by a Brønsted acid. β-Diketones and β-keto esters are both well tolerated to give the corresponding products in moderate to excellent yields.