Regulation of fetal growth by the somatotrophic axis
Regulation of fetal growth by the somatotrophic axis
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DOI：
10.1093/jn/133.5.1741s
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发表时间：
2003-05-01
影响因子：
4.2
通讯作者：
Pinal, CS
中科院分区：
文献类型：
--
作者：
Gluckman, PD;Pinal, CS
不理想的胎儿生长与较高的胎儿死亡率和较高的新生儿发病率和死亡率有关。它增加了早产的可能性，从而进一步加剧了围产期健康风险。此外，异常的胎儿环境，如出生尺寸表型改变所反映的，增加了儿童期和成年期的疾病倾向。胎儿生长代表了胎儿基因组和由配偶胎盘功能决定的子宫内环境相互作用的高潮。本文将对内分泌和代谢因素在这种相互作用中的作用进行综述。还有证据表明，在妊娠后期测量的胎儿生长不仅取决于母体环境，还取决于围孕期发生的事件。因此，胎儿生长不仅反映了直接的胎儿环境，而且反映了围绕受孕和胚胎生命的事件。
Suboptimal fetal growth is associated with higher fetal mortality and with higher neonatal morbidity and mortality. It increases the likelihood of premature birth that in turn further compounds perinatal health risks. Moreover, an abnormal fetal environment, as reflected in an altered birth size phenotype, increases the propensity for disease in childhood and adulthood. Fetal growth represents the culmination of interaction between the fetal genome and the in utero environment determined by mate mal-placental function. The role of endocrine and metabolic factors in mediating this interaction will be reviewed. There is also evidence that fetal growth, as measured in late gestation, is dependent not only on the maternal environment but on events that occurred during the periconceptual period. Thus, fetal growth not only reflects the immediate fetal environment but events surrounding conception and embryonic life.