Potential adverse health effects of ingested micro- and nanoplastics on humans. Lessons learned from in vivo and in vitro mammalian models
Potential adverse health effects of ingested micro- and nanoplastics on humans. Lessons learned from in vivo and in vitro mammalian models
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DOI：
10.1080/10937404.2019.1700598
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发表时间：
2019-12
期刊：
影响因子：
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通讯作者：
Laura Rubio;R. Marcos;Alba Hernández
中科院分区：
文献类型：
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作者：
Laura Rubio;R. Marcos;Alba Hernández
近年来，“微塑料”(MPS)和“纳米塑料”(NPs)引起了全球越来越多的关注，导致了许多关于这些化合物对生态和环境影响的研究。这些微小颗粒(<；5000微米)，主要来自塑料的降解，污染海洋和陆地生态系统，并有能力进入食物链。在这种情况下，人类食用被MPS或NPS污染的食品是不可避免的，但相关的后果仍有待确定。这篇综述的目的是通过提供有关哺乳动物体内和体外系统暴露、吸收和毒性的新研究，来补充以前关于这一主题的综述。关于新的信息，查明了妨碍得出坚定结论和编制可靠风险评估的差距和限制。随后，提出了体内和体外测试方法的建议，以便进行进一步的相关和有针对性的研究。
ABSTRACT In recent years, increasing global attention has focused on “microplastics” (MPs) and “nanoplastics” (NPs) resulting in many studies on the effects of these compounds on ecological and environmental aspects. These tiny particles (<5000 µm), predominantly derived from the degradation of plastics, pollute the marine and terrestrial ecosystems with the ability to enter into the food chain. In this manner, human consumption of food contaminated with MPs or NPs is unavoidable, but the related consequences remain to be determined. The aim of this review is to complement previous reviews on this topic by providing new studies related to exposure, absorption, and toxicity in mammalian in vivo and in vitro systems. With respect to novel information, gaps and limitations hindering attainment of firm conclusions as well as preparation of a reliable risk assessment are identified. Subsequently, recommendations for in vivo and in vitro testing methods are presented in order to perform further relevant and targeted research studies.