Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking G alpha q
Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking G alpha q
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DOI：
10.1073/pnas.94.25.14089
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发表时间：
1997-12-09
影响因子：
11.1
通讯作者：
Simon, MI
中科院分区：
文献类型：
--
作者：
Offermanns, S;Hashimoto, K;Simon, MI
缺乏异源三聚鸟嘌呤核苷酸结合蛋白 G(q) (G alpha(q)) α 亚基的小鼠可以存活，但患有共济失调，并伴有典型的运动失调症状。小脑的解剖结构没有受到明显的干扰，从平行纤维到小脑浦肯野细胞 (PC) 以及从攀爬纤维 (CF) 到 PC 的兴奋性突触传递是有功能的。然而，大约 40% 的成人 G α(q) 突变 PC 仍然受到 CF 的多重神经支配，因为出生后第三周多余 CF 的消退存在缺陷。有证据表明 G α 7q 是参与消除该时期多重 CF 神经支配的信号传导途径的一部分。
Mice lacking the alpha-subunit of the heterotrimeric guanine nucleotide binding protein G(q) (G alpha(q)) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of the cerebellum Is not overtly disturbed, and excitatory synaptic transmission from parallel fibers to cerebellar Purkinje cells (PCs) and from climbing fibers (CFs) to PCs is functional. However, about 40% of adult G alpha(q) mutant PCs remain multiply innervated by CFs because of a defect in regression of supernumerary CFs in the third postnatal week. Evidence Is provided suggesting that G alpha 7q is part of a signaling pathway that is involved in the elimination of multiple CF innervation during this period.