Smart H2O2-Responsive Drug Delivery System Made by Halloysite Nanotubes and Carbohydrate Polymers
Smart H2O2-Responsive Drug Delivery System Made by Halloysite Nanotubes and Carbohydrate Polymers
复制标题
由埃洛石纳米管和碳水化合物聚合物制成的智能 H2O2 响应药物递送系统
DOI：
10.1021/acsami.7b10867
复制
发表时间：
2017-09-20
影响因子：
9.5
通讯作者：
Ba, Xinwu
中科院分区：
文献类型：
--
作者：
Liu, Feng;Bai, Libin;Ba, Xinwu
将1，4-苯二硼酸修饰的埃洛石纳米管(HNTs-BO)与可压缩淀粉偶联，制备了一种新型的化学水凝胶。用固体核磁共振、傅里叶变换红外光谱、扫描电子显微镜和透射电子显微镜对改性后的埃洛石纳米管和水凝胶进行了表征。在H_2O_2存在下，凝胶中的B-C键可被降解为B-OH和C-OH单元，从而导致化学水凝胶的降解。将己酮可可碱负载到HNTs-BO的管腔内，然后给出己酮可可碱水凝胶。药物释放曲线显示，以磷酸盐缓冲溶液(PBS)为释药介质时，其溶出度不超过7%。值得注意的是，添加H_2O_2([H_2O_2]=1×10~(-4)M)可以实现完全释放(接近90%)，这表明所形成的水凝胶具有很高的H_2O_2响应性。药物释放结果还表明，通过将己酮可可碱负载到HNTs的管腔内，而不是将药物包埋在水凝胶网络中，可以有效地抑制HNTs的“初始突发释放”。这种具有过氧化氢响应释放行为的载药水凝胶可能在生物医学领域开辟更广泛的应用。
A novel chemical hydrogel was facilely achieved by coupling 1,4-phenylenebisdiboronic acid modified halloysite nanotubes (HNTs-BO) with compressible starch. The modified halloysite nanotubes (HNTs) and prepared hydrogel were characterized by solid-state nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscope (TEM). The linkage of B-C in the hydrogel can be degraded into B-OH and C-OH units in the presence of H2O2 and result in the degradation of the chemical hydrogel. Pentoxifylline was loaded into the lumen of the HNTs-BO, and then gave the pentoxifylline-loaded hydrogel. The drug release profile shows that it was no more than 7% dissolved when using phosphate buffer solution (PBS) as the release medium. Notably, a complete release (near 90%) can be achieved with the addition of H2O2 ([H2O2] = 1 x 10(-4) M), suggesting a high H2O2 responsiveness of the as-formed hydrogel. The drug release results also show that the "initial burst release" can be effectively suppressed by loading pentoxifylline inside the lumen of the HNTs rather than embedding the drug in the hydrogel network. The drug-loaded hydrogel with H2O2-responsive release behavior may open up a broader application in the field of biomedicine.