Total Synthesis of (+)-Decarbamoylsaxitoxin and (+)-Gonyautoxin 3
Total Synthesis of (+)-Decarbamoylsaxitoxin and (+)-Gonyautoxin 3
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DOI：
10.1021/ol1006696
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发表时间：
2010-05-07
期刊：
影响因子：
5.2
通讯作者：
Nagasawa, Kazuo
中科院分区：
文献类型：
--
作者：
Iwamoto, Osamu;Nagasawa, Kazuo
复杂蛤蚌毒素（STX）骨架的简单构建是通过使用一种新型的、构象控制的胍环化过程进行的，该过程依赖于邻近基团的参与。该方法的效用是通过其在天然和非天然STX衍生物的合成中的应用来验证的。
Facile construction of the complex saxitoxin (STX) skeleton is carried out by using a novel, conformationally controlled, guanidine cyclization process that relies on the use of neighboring group participation. The utility of this methodology is verified by its employment in syntheses of both natural and unnatural STX derivatives.