Psychopharmacology and the etiology of psychopathologic states: are we looking in the right way?
Psychopharmacology and the etiology of psychopathologic states: are we looking in the right way?
复制标题
精神药理学和精神病理状态的病因学：我们的研究方向正确吗？
DOI：
10.1038/npp.1994.16
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Maas,JW
中科院分区：
文献类型：
--
作者：
Katz,MM;Maas,JW
讨论了为什么研究还没有能够确定任何已知的精神疾病的神经生物学基础的性质，为什么仍然没有明确的证据，如吩噻嗪，锂，三环类药物的作用，使这些疾病的决议。这表明，研究混淆了精神药物对主要疾病（焦虑和抑郁症的运动行为，精神分裂症的精神病）的组分的多种作用，并假定对核心障碍的影响，因此，错误地假设某些中枢神经递质系统与疾病的核心有关，而不仅仅是与其组分有关。（PsycInfo数据库记录（c）2016阿帕，保留所有权利）
Discusses why research has not been able to establish definitively the nature of the neurobiologic basis of any known psychiatric disorder and why there is still no clear evidence for how such drugs as phenothiazines, lithium, and the tricyclic drugs act to bring about resolution of these disorders. It is suggested that research has confused the multiple actions of psychotropic drugs on components of the main illness (anxiety and motor behavior in depression, psychosis in schizophrenia) with presumed effects on the core disturbance and, as such, have falsely hypothesized that certain central neurotransmitter systems are associated with the core of the illness rather than with its components only.(PsycINFO Database Record (c) 2016 APA, all rights reserved)