Diterpenoids from Salvia miltiorrhiza and Their Immune-Modulating Activity
Diterpenoids from Salvia miltiorrhiza and Their Immune-Modulating Activity
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丹参二萜类化合物及其免疫调节作用
DOI：
10.1021/acs.jafc.7b02384
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发表时间：
2017-07-26
影响因子：
6.1
通讯作者：
Gao, Kun
中科院分区：
文献类型：
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作者：
Wei, Wen-Jun;Zhou, Pan-Pan;Gao, Kun
丹参，唇形科丹参的干燥根，是中国最常用的传统草药之一。近年来，丹参在中国已被用作保健功能茶，通过增强人体免疫力来预防疾病。为了寻找具有免疫调节活性的次生代谢产物，对丹参根进行了植物化学研究，分离出 6 种新的二萜化合物（1-4、16 和 20）以及 20 种已知的二萜化合物。基于光谱分析、X射线衍射分析、计算旋光度和计算电子圆二色光谱，阐明了这些新化合物的结构和绝对构型。在这些分离物中，化合物3、17、19和23促进HMy2.CIR的增殖，在2.50至40μM的浓度下对淋巴细胞表现出保护作用，而化合物2、7、8、10、14、18、22和25以浓度依赖性方式抑制细胞增殖。
Danshen, the dried root of Salvia miltiorrhiza (Lamiaceae), is one of the most popular traditional herbal medicines commonly used in China. Recently, danshen has been used as a health-promoting functional tea to prevent diseases by strengthening the human immunity in China. To search for secondary metabolites with immune-modulating activity, a phytochemical investigation was carried out on the roots of S. miltiorrhiza, which led to the isolation of 6 new diterpenoids (1-4, 16, and 20) along with 20 known diterpenoids. The structures and absolute configurations of these new compounds were elucidated on the basis of spectroscopic analysis, X-ray diffraction analysis, calculated optical rotation, and calculated electronic circular dichroism spectra. Among these isolates, compounds 3, 17, 19, and 23 promoted the proliferation of HMy2.CIR, exhibiting a protective effect on lymphocytes at the concentration from 2.50 to 40 mu M, whereas compounds 2, 7, 8, 10, 14, 18, 22, and 25 inhibited the cell proliferation in a concentration-dependent manner.