EFFECTS OF AN ORGANO-PHOSPHATE (DICHLORVOS) ON OPEN-FIELD BEHAVIOR AND LOCOMOTOR-ACTIVITY - CORRELATION WITH REGIONAL BRAIN MONOAMINE LEVELS
EFFECTS OF AN ORGANO-PHOSPHATE (DICHLORVOS) ON OPEN-FIELD BEHAVIOR AND LOCOMOTOR-ACTIVITY - CORRELATION WITH REGIONAL BRAIN MONOAMINE LEVELS
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DOI：
10.1007/bf00426647
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发表时间：
1980-01-01
影响因子：
3.4
通讯作者：
HASAN, M
中科院分区：
文献类型：
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作者：
ALI, SF;CHANDRA, O;HASAN, M
一组白化病大鼠每天腹腔注射敌敌畏（O，O-二甲基-2：2-二氯乙烯基磷酸酯）农药（3 mg/kg），连续10天。旷场行为显著低于对照组的平均值。在第7天，amplitude降低至平均值的24%，但在第10天恢复至60%。饲养反应在第7天下降，并在第10天表现出快速恢复，但理羽反应在第10天进一步下降。排便在第7天被抑制至0%，并在第10天显示完全恢复。运动活动在第二阶段表现出明显的抑制，精细运动比粗大运动减少更多。多巴胺在第5天和第7天显著降低，但在第10天脑干中显示出13%的恢复。大脑半球去甲肾上腺素显著减少，而大脑半球和脑干5-羟色胺均减少。这2种胺在第10天均未显示显著恢复。有趣的一致性的开放领域的行为变化与多巴胺，去甲肾上腺素和5-羟色胺在大鼠大脑的各个区域的水平是值得注意的，并进行了讨论。
Dichlorvos (O,O-dimethyl-2:2-dichlorovinyl phosphate), a pesticide, was administered i.p. (3 mg/kg) daily for 10 days to a group of albino rats. Open-field behavior was significantly depressed below the mean of the control group. On day 7, ambulation was reduced to 24% of the mean but recovered to 60% on day 10. Rearing response was decreased on day 7 and showed a fast recovery on day 10 but the preening response further declined on day 10. Defecation was suppressed to 0% on day 7 and showed complete recovery on day 10. Motor activity showed a significant depression and fine movements were reduced more than gross movements in the 2nd phase. Dopamine was significantly decreased on days 5 and 7 but showed a 13% recovery in the brain stem on day 10. Norepinephrine was significantly reduced in the cerebral hemisphere while serotonin was decreased both in cerebral hemisphere and brain stem. Neither of these 2 amines showed significant recovery on day 10. Interesting concordance of the open-field behavioral changes with the levels of dopamine, norepinephrine and serotonin in the various regions of the rat brain was noticeable and was discussed.