Acquired immune deficiency syndrome. Ocular manifestations.
Acquired immune deficiency syndrome. Ocular manifestations.
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DOI：
10.1016/s0161-6420(83)80009-8
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发表时间：
1983-08
期刊：
影响因子：
13.7
通讯作者：
G. Holland;G. Holland;J. Pepose;T. H. Pettit;T. H. Pettit;M. Gottlieb;R. Yee;R. Yee;R. Foos;R. Foos
中科院分区：
文献类型：
--
作者：
G. Holland;G. Holland;J. Pepose;T. H. Pettit;T. H. Pettit;M. Gottlieb;R. Yee;R. Yee;R. Foos;R. Foos
获得性免疫缺陷综合症（艾滋病）是最近描述的同性恋者、静脉注射毒品滥用者和海地人的细胞免疫紊乱。表现包括卡波西肉瘤、卡氏肺孢子虫肺炎和其他机会性感染。加州大学洛杉矶分校对 30 名患者进行的眼科和尸检检查显示，经常出现眼部异常。结果包括棉絮斑（16 名患者）、巨细胞病毒性视网膜炎（8 名患者）、结膜炎和角膜炎（4 名患者）、结膜卡波西肉瘤（3 名患者）、鸟分枝杆菌细胞内脉络膜肉芽肿（1 名患者）和视网膜静脉周炎（1 名患者）。我们认为，这种综合征患者出现棉絮斑表明预后不良。对棉毛斑点的免疫学和电子显微镜研究表明没有传染性物质或免疫球蛋白沉积。巨细胞病毒性视网膜炎总是与致命的结果相关。视网膜炎的特点是 50% 的患者出现急性炎症反应。眼科医生应该了解该综合征及其眼部表现。
The acquired immune deficiency syndrome (AIDS) is a recently described disorder of cellular immunity in homosexuals, intravenous drug abusers, and Haitians. Manifestations include Kaposi's sarcoma,Pneumocystis cariniipneumonia, and other opportunistic infections. Ophthalmic and autopsy examinations of 30 patients at UCLA revealed frequent ocular abnormalities. Findings included cotton-wool spots (16 patients), cytomegalovirus retinitis (eight patients), conjunctivitis and keratitis (four patients), conjunctival Kaposi's sarcoma (three patients),Mycobacterium avium intracellularechoroidal granulomas (one patient), and retinal periphlebitis (one patient). We feel that the presence of cotton-wool spots in patients with this syndrome indicates a poor prognosis. Immunologic and electronmicroscopic studies of cotton-wool spots revealed no infectious agents or immunoglobulin deposition. Cytomegalovirus retinitis always was associated with a fatal outcome. The retinitis was characterized by an acute inflammatory reaction in 50% of patients. Ophthalmologists should be aware of the syndrome and its ocular manifestations.