High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma
High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma
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DOI：
10.1182/blood-2006-04-018218
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发表时间：
2006-11-01
期刊：
影响因子：
20.3
通讯作者：
Banham, Alison H.
中科院分区：
文献类型：
--
作者：
Carreras, Joaquim;Lopez-Guillermo, Armando;Banham, Alison H.
肿瘤微环境在滤泡性淋巴瘤（FL）的生物学行为中起着重要作用，但参与这种调节的特定细胞亚群尚不清楚。为了确定FOXP3阳性调节性T细胞（TCFs）在FL患者进展和结局中的影响，我们用抗FOXP3单克隆抗体检查了97例诊断患者和37例首次复发患者的样本。使用计算机图像分析对调节性T细胞进行定量。中位总生存期（OS）为9.9年，FL国际预后指数（FLIPI）具有统计学意义。诊断时Treg百分比中位数为10.5%。总体而言，49例患者的TBI超过10%，30例在5%至10%之间，19例小于5%，5年OS分别为80%、74%和50%（P = 0.001）。极低数量THBE（< 5%）的患者更常出现难治性疾病（P = 0.007）。Treg数量的预后意义与FLIPI无关。7例转化的弥漫性大B细胞淋巴瘤（DLBCL）的Treg百分比（平均值：3.3%）低于FL 1、2级（平均值：12.1%）或3级（平均值：9%）（P <0.02）。总之，高Treg数量预测FL患者的存活率改善，而在转化为DLBCL时观察到Tlag显著降低。
The tumor microenvironment plays an important role in the biologic behavior of follicular lymphoma (FL), but the specific cell subsets involved in this regulation are unknown. To determine the impact of FOXP3-positive regulatory T cells (Tregs) in the progression and outcome of FL patients, we examined samples from 97 patients at diagnosis and 37 at first relapse with an anti-FOXP3 monoclonal antibody. Tregs were quantified using computerized image analysis. The median overall survival (OS) of the series was 9.9 years, and the FL International Prognostic Index (FLIPI) was prognostically significant. The median Treg percentage at diagnosis was 10.5%. Overall, 49 patients had more than 10% Tregs, 30 between 5% to 10%, and 19 less than 5%, with a 5-year OS of 80%, 74%, and 50%, respectively (P = .001). Patients with very low numbers of Tregs (< 5%) presented more frequently with refractory disease (P = .007). The prognostic significance of Treg numbers was independent of the FLIPI. Seven transformed diffuse large B-cell lymphomas (DLBCLs) had lower Treg percentages (mean: 3.3%) than FL grades 1,2 (mean: 12.1%) or 3 (mean: 9%) (P < .02). In conclusion, high Treg numbers predict improved survival of FL patients, while a marked reduction in Tregs is observed on transformation to DLBCL.