Lamellar organization of hippocampal excitatory pathways
Lamellar organization of hippocampal excitatory pathways
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DOI：
10.1007/bf00234087
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发表时间：
1971-08
影响因子：
2
通讯作者：
P. Andersen;T. Bliss;K. Skrede
中科院分区：
文献类型：
--
作者：
P. Andersen;T. Bliss;K. Skrede
1.海马皮质的内嗅激活涉及四元通路的顺序激活：来自内嗅区的穿通通路-来自齿状颗粒细胞的苔藓纤维-CA 3锥体细胞的Schaffer侧支，最后，2.通过记录细胞外场电位研究了这四种纤维束的空间取向（群体尖峰），发出神经元响应顺向或逆向冲动的放电信号。3.内嗅区相邻部分的穿通通路纤维以平行的方式在几乎垂直于海马纵轴的方向上延伸。在海马的背侧部分，这个方向几乎是矢状的，证实了Lømo（1971 a）。苔藓纤维以及Schaffer侧枝和阿尔韦亚纤维都被发现在同一方向运行。因此，内嗅活动的点源通过四元通路沿着海马组织的薄片或薄层投射其冲动，该薄片或薄层垂直于海马结构的背侧部分的阿尔韦亚表面并接近矢状。此外，刺激电极和记录电极的时间位置越多，板层组织保持不变，但方向不同，与海马的弯曲相匹配，使得板层平面与纵轴之间的角度保持不变。4.通过注射快速凝固的醋酸乙烯酯溶液，显示海马结构中动脉和静脉的方向。5.海马皮质的神经元和血管系统似乎是平行排列的。通过这种板层组织，海马皮质的小条可以作为独立的功能单位运作，尽管兴奋性和抑制性横向连接可以改变相邻板层的行为。
1.Entorhinal activation of the hippocampal cortex involves the sequential activation of a four-membered pathway: the perforant path from the entorhinal area — the mossy fibres from the dentate granule cells — the Schaffer collaterals of the CA3 pyramidal cells and finally, the CA1 pyramidal cell axons in the alveus.2.The spatial orientation of these four fibre bundles has been studied by recording the extracellular field potentials (population spike), signalling the discharge of neurones in response to orthodromic or antidromic impulses. The height of the population spike was taken as an indicator of the number of cells discharged (see the previous paper).3.The perforant path fibres from neighbouring parts of the entorhinal area run in a parallel fashion in a direction nearly transversely to the longitudinal axis of the hippocampus. In the dorsal part of the hippocampus, this direction was nearly sagittal, confirming Lømo (1971 a). The mossy fibres as well as the Schaffer collaterals and the alvear fibres were all found to run in the same direction. Thus, a point source of entorhinal activity projects its impulses through the four-membered pathway along a slice, or lamella, of hippocampal tissue oriented normally to the alvear surface and nearly sagittally in the dorsal part of the hippocampal formation. Also with more temporal locations of the stimulating and recording electrodes, the lamellar organization was maintained, but with a different orientation, matching the curving of the hippocampus so that the angle between the plane of the lamella and the longitudinal axis remained the same.4.By injection of a quick-setting solution of vinyl acetate, the direction of the arteries and veins in the hippocampal formation was displayed. The branches from the artery running in the hippocampal fissure are nearly straight and are oriented in a direction similar to that of the lamellae.5.The hippocampal cortex seems to be organized in parallel lamellae, both with regard to the neuronal and the vascular system. By means of this lamellar organization, small strips of the hippocampal cortex may operate as independent functional units, although excitatory and inhibitory transverse connections may modify the behaviour of the neighbouring lamellae.