A subcortical oscillatory network contributes to recovery of hand dexterity after spinal cord injury.
A subcortical oscillatory network contributes to recovery of hand dexterity after spinal cord injury.
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DOI：
10.1093/brain/awn338
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Isa T
中科院分区：
文献类型：
--
作者：
Nishimura Y;Morichika Y;Isa T
最近的研究表明，在中颈段的部分脊髓损伤后，剩余的通路补偿恢复手指的灵活性;然而，它们如何控制手/手臂肌肉仍然不清楚。为了阐明连接运动皮层和手/手臂肌肉的神经回路的动态特性的变化，我们研究了脊髓损伤后整个恢复期的皮层和肌肉间的活动耦合。损伤后1个月，拮抗肌对的活动显示出共激活，并在30-46 Hz（γ-带）频率上连贯振荡。这种γ-带肌间耦合在损伤前没有观察到，但随着恢复而出现并加强，并分布在广泛的手/臂肌肉沿着。损伤前未观察到β-波段（14-30 Hz）的皮质-肌肉耦合，损伤后也未观察到运动皮层的γ-波段振荡。我们建议，皮层下振荡器通常招募手/手臂肌肉，通过剩余的途径，如网状脊髓和/或propriospinal束，独立于皮层振荡，并有助于功能恢复。
Recent studies have shown that after partial spinal-cord lesion at the mid-cervical segment, the remaining pathways compensate for restoring finger dexterity; however, how they control hand/arm muscles has remained unclear. To elucidate the changes in dynamic properties of neural circuits connecting the motor cortex and hand/arm muscles, we investigated the cortico- and inter-muscular couplings of activities throughout the recovery period after the spinal-cord lesion. Activities of antagonist muscle pairs showed co-activation and oscillated coherently at frequencies of 30–46 Hz (γ-band) by 1-month post-lesion. Such γ-band inter-muscular coupling was not observed pre-lesion, but emerged and was strengthened and distributed over a wide range of hand/arm muscles along with the recovery. Neither the β-band (14–30 Hz) cortico-muscular coupling observed pre-lesion nor a γ-band oscillation was observed in the motor cortex post-lesion. We propose that a subcortical oscillator commonly recruits hand/arm muscles, via remaining pathways such as reticulospinal and/or propriospinal tracts, independent of cortical oscillation, and contributes to functional recovery.
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