Intracerebral hemorrhage in two patients with Down's syndrome and cerebral amyloid angiopathy
Intracerebral hemorrhage in two patients with Down's syndrome and cerebral amyloid angiopathy
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DOI：
10.1007/s004010050789
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发表时间：
1998-02-01
影响因子：
12.7
通讯作者：
Adelman, LS
中科院分区：
文献类型：
--
作者：
Donahue, JE;Khurana, JS;Adelman, LS
脑淀粉样血管病（CAA）是老年人自发性脑出血的重要原因，常见于阿尔茨海默病、唐氏综合症（DS）和荷兰型淀粉样变性遗传性脑出血患者的大脑中。我们报告了两名患有 DS 和广泛 CAA 的患者死于脑出血；文献中仅存在另外两例此类病例报告。我们认为此类病例的发生率比报道的要高，并且 CAA 发生出血的可能性与患者的基础疾病无关。
Cerebral amyloid angiopathy (CAA) is an important cause of spontaneous intracerebral hemorrhages in the elderly and is often seen in the brains of patients with Alzheimer's disease, Down's syndrome (DS), and hereditary cerebral hemorrhage with amyloidosis of the Dutch type. We report two patients with DS and extensive CAA who died of intracerebral hemorrhage; only two other such case reports exist in the literature. We believe the incidence of such cases is higher than is reported and that the likelihood of hemorrhage in the setting of CAA is independent of the patient's underlying disease.