Changes in thyroid antibody and T lymphocyte subsets after radiofrequency ablation of thyroid nodules in patients with autoimmune thyroiditis
Changes in thyroid antibody and T lymphocyte subsets after radiofrequency ablation of thyroid nodules in patients with autoimmune thyroiditis
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自身免疫性甲状腺炎患者甲状腺结节射频消融术后甲状腺抗体及T淋巴细胞亚群的变化
DOI：
10.4103/jcrt.jcrt_1421_20
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发表时间：
2021-07
影响因子：
1.3
通讯作者：
Xiaoli Zhu
中科院分区：
文献类型：
--
作者：
Xiaoyin Tang;Ping Li;Bo Zhai;Xiaoli Zhu
设置和设计：目的：探讨射频消融（RFA）治疗自身免疫性甲状腺炎患者甲状腺结节后甲状腺抗体及T淋巴细胞亚群的变化。受试者和方法：对患有自身免疫性甲状腺炎和甲状腺结节的患者（n = 135）进行RFA治疗。分别于术前、术后第1天、术后第1个月检测甲状腺功能、甲状腺抗体及T淋巴细胞亚群。记录任何并发症。统计学分析：使用在Windows 8下运行的软件SPSS 17.0.0（版本：2008-8-23）进行统计学分析。测量数据以x ± s表示，P < 0.01表示统计学数据有显著性差异。结果如下：消融前游离三碘甲状腺原氨酸、游离甲状腺素和促甲状腺激素水平均在正常范围内，消融后第1天或第1个月无显著变化。CD 8 +T细胞百分率和B细胞绝对值变化无统计学意义（P > 0.01），均在正常范围内。与术前比较，术后第1天TG Ab、TPO Ab、CD 4 +/CD 8+、CD 4 +T细胞百分比、淋巴细胞绝对值、T细胞绝对值、CD 4 +T细胞绝对值、CD 8 +T细胞绝对值均显著下降（P <0.0 1），术后30天恢复至术前水平（P > 0.0 1）。结论：自身免疫性甲状腺炎患者行甲状腺结节射频消融术后，甲状腺功能不受影响，无严重并发症发生。消融术后短期内可明显降低TG-Ab和TPO-Ab水平，改变T淋巴细胞亚群分布。
Settings and Design: The aim was to study the changes in thyroid antibody and T lymphocyte subsets after radiofrequency ablation (RFA) of thyroid nodules in patients with autoimmune thyroiditis. Subjects and Methods: Patients (n = 135) with autoimmune thyroiditis and thyroid nodules were treated by RFA. The indices of thyroid function and thyroid antibody and T lymphocyte subsets were examined preoperation and on the 1st day and the 1st month after ablation. Any complications were recorded. Statistical Analysis: The software SPSS 17.0.0 (version: 2008-8-23) running under Windows 8 was used for statistical analysis. The measurement data were expressed as x ± s, with P < 0.01 indicating a significant difference in the statistical data. Results: Levels of free triiodothyronine, free thyroxine, and thyroid-stimulating hormone were in the normal range before ablation, and no significant changes occurred on the 1st day or in the 1st month after ablation. The change in the percentage of CD8+T cells and the absolute value of B cells were not statistically significant (P > 0.01), and the values were in the normal range. Compared with values recorded preoperation, the value of TG-Ab, TPO-Ab, CD4+/CD8+, the percentage of CD4+T cells, the absolute values of lymphocytes, T cells, CD4+T cells, and CD8+T cells decreased significantly at the 1st day after ablation (P < 0.01) and then recovered to preoperative levels during the first 30 days after ablation (P > 0.01). Within 1 month after ablation, none of the patients had complications such as active bleeding, infection, recurrent laryngeal nerve injury, parathyroid gland injury, skin scald, and so on. Conclusions: After RFA of thyroid nodules in patients with autoimmune thyroiditis, thyroid function is not affected and no serious complications occurred. TG-Ab and TPO-Ab levels can be significantly decreased, and the distribution of T lymphocyte subsets can be changed in the short term after ablation.