Development and characterization of an anthropomorphic breast software phantom based upon region-growing algorithm
Development and characterization of an anthropomorphic breast software phantom based upon region-growing algorithm
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DOI：
10.1118/1.3590357
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发表时间：
2011-06-01
期刊：
影响因子：
3.8
通讯作者：
Maidment, Andrew D. A.
中科院分区：
文献类型：
--
作者：
Bakic, Predrag R.;Zhang, Cuiping;Maidment, Andrew D. A.
目的：我们提出了一种新的算法，用于计算机模拟乳房解剖生成拟人软件乳房模型。一个现实的乳房模拟是必要的体积imaging models.Methods的临床前验证：拟人软件乳房幻影模拟皮肤，脂肪和纤维腺体组织的区域，和矩阵的库珀的韧带和脂肪隔间。使用种子区域生长算法模拟脂肪隔室;隔室从具有特定方向和生长速度的一组种子点生长。所得脂肪区室在形状和大小上变化，类似于真实的乳房;脂肪区域具有由各种大小的脂肪区室紧密覆盖，而纤维腺体区域具有更少的、更广泛分离的脂肪区室。模拟参数可以选择，以涵盖乳房解剖结构的变化的宽度，在临床observed.Results：当模拟乳房相同的腺体与不同数量的脂肪隔间，平均隔间体积成正比的幻影大小和模拟隔间的数量成反比。通过体模的合成数字乳腺断层合成图像说明了软件体模在临床图像模拟中的使用。所提出的体模设计能够模拟不同大小、腺体和脂肪室分布的乳房。区域生长方法允许我们模拟具有各种大小和形状的脂肪隔室。定性，模拟X射线投影的幻影，使用所提出的算法生成的，有一个更现实的外观相比，以前版本的phantom.Conclusions：一个新的算法，计算机模拟乳房解剖结构已被提出，提高了现实的拟人软件乳房幻影。(C)2011年美国医学物理学家协会。[DOI：10.1118/1.3590357]
Purpose: We present a novel algorithm for computer simulation of breast anatomy for generation of anthropomorphic software breast phantoms. A realistic breast simulation is necessary for preclinical validation of volumetric imaging modalities.Methods: The anthropomorphic software breast phantom simulates the skin, regions of adipose and fibroglandular tissue, and the matrix of Cooper's ligaments and adipose compartments. The adipose compartments are simulated using a seeded region-growing algorithm; compartments are grown from a set of seed points with specific orientation and growing speed. The resulting adipose compartments vary in shape and size similar to real breasts; the adipose region has a compact coverage by adipose compartments of various sizes, while the fibroglandular region has fewer, more widely separated adipose compartments. Simulation parameters can be selected to cover the breadth of variations in breast anatomy observed clinically.Results: When simulating breasts of the same glandularity with different numbers of adipose compartments, the average compartment volume was proportional to the phantom size and inversely proportional to the number of simulated compartments. The use of the software phantom in clinical image simulation is illustrated by synthetic digital breast tomosynthesis images of the phantom. The proposed phantom design was capable of simulating breasts of different size, glandularity, and adipose compartment distribution. The region-growing approach allowed us to simulate adipose compartments with various size and shape. Qualitatively, simulated x-ray projections of the phantoms, generated using the proposed algorithm, have a more realistic appearance compared to previous versions of the phantom.Conclusions: A new algorithm for computer simulation of breast anatomy has been proposed that improved the realism of the anthropomorphic software breast phantom. (C) 2011 American Association of Physicists in Medicine. [DOI: 10.1118/1.3590357]