INTERMITTENT MICROMOTION AND POLYETHYLENE PARTICLES INHIBIT BONE INGROWTH INTO TITANIUM CHAMBERS IN RABBITS
INTERMITTENT MICROMOTION AND POLYETHYLENE PARTICLES INHIBIT BONE INGROWTH INTO TITANIUM CHAMBERS IN RABBITS
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DOI：
10.1002/jab.770060303
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发表时间：
1995-09-01
期刊：
影响因子：
--
通讯作者：
LIDGREN, L
中科院分区：
文献类型：
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作者：
GOODMAN, S;ASPENBERG, P;LIDGREN, L
采用组织形态和形态计量学方法，观察了每日短时间微运动和高密度聚乙烯(PE)可吞噬颗粒对兔1×1×5 mm钛腔内植入1×1×5 mm骨管的影响。在骨整合和第一次采集组织后，以1 Hz的频率每天施加40个微动(幅度=0.5 mm)，连续3周，然后采集腔体内的组织，第二个处理是将10(8)个/mL的PE颗粒放置到根管内，3周后收获腔体内的组织，下一个处理是3周的休息期，其中不使用微动也不使用颗粒；随后是收获，最后的处理结合了PE颗粒和微运动，3周后，对照收获的切片包含广泛的小梁骨，纵向排列在整个管内的纤维血管间质中，微运动在腔内产生纵向定向的纤维组织，PE颗粒与巨噬细胞相关联，包围和吞噬双折射颗粒，颗粒和微运动的组合产生含有巨噬细胞的纤维基质，PE颗粒和微运动单独或联合产生类似的抑制骨生长的作用，与没有颗粒的未移动的腔相比，在这个短期的实验中，这两种刺激没有相加或增强的作用。(C)1995 John Wiley and Sons，Inc.
We performed a histomorphological and morphometric analysis of the effects of short daily periods of micromotion and phagocytosable particles of high density polyethylene (PE) an bone ingrowth into a 1 X 1 X 5 mm canal within a titanium chamber in rabbits, The micromotion chamber (MC) was implanted in the tibia of nine mature New Zealand white rabbits; After osseointegration and first harvest of tissue, 40 micromotions (amplitude = 0.5 mm) were applied daily at a rate of I Hz for a 3-week period, The tissue within the chamber was then harvested, For the second treatment, PE particles (10(8)/mL) were placed within the canal, The tissue in the chamber was harvested 3 weeks later, The next treatment was a 3-week rest period, in which neither micromotion nor particles were utilized; a harvest followed, The final treatment combined PE particles and micromotion, followed by a harvest 3 weeks later, Sections from control harvests contained extensive trabecular bone arranged longitudinally throughout the canal in a fibrovascular stroma, Micromotion produced longitudinally oriented fibrous tissue within the chamber, PE particles were associated with macrophages, surrounding and engulfing the birefringent particles, The combination of particles and micromotion produced a fibrous stroma laden with macrophages, PE particles and micromotion, alone or together, produced a similar effect in inhibiting bone ingrowth, compared to nonmoved chambers without particles, In this short-term experiment, no additive or potentiating effect of these two stimuli could be demonstrated. (C) 1995 John Wiley and Sons, Inc.