A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women
A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women
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DOI：
10.1016/s0021-9150(02)00423-9
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发表时间：
2003-03-01
期刊：
影响因子：
5.3
通讯作者：
Sacchetti, L
中科院分区：
文献类型：
--
作者：
Fortunato, G;Rubba, P;Sacchetti, L
对氧磷酶 (PON) 基因多态性已被提议作为心血管疾病 (CVD) 风险的遗传标记。零星结果表明它们与内膜中层厚度（IMT）相关，IMT 是临床前动脉粥样硬化疾病的指标。我们在 310 名中年女性中研究了 PON 1 (M/L) 55、(Q/R) 192、PON 2 (S/C) 311 多态性是否与位点特异性颈动脉斑块相关。还研究了受试者的物理和生化参数，包括氧化标记物，以评估其对高分辨率 B 型超声识别的动脉粥样硬化斑块（IMT > 1.2 mm）发展的影响。我们证明 PON 1 (LL + ML) 55 与分叉处 (OR = 2.40; 95% CI 1.00-5.90) 和颈总动脉 (OR = 2.75; 95% CI 1.01-7.50) 处的斑块相关，并且与任何部位的斑块总数相关 (P < 0.05)。该多态性是相对于与斑块显着相关的其他变量的独立参数，即颈动脉斑块情况下的收缩压（OR = 2.06；95% CI 1.11-3.81）和氧化低密度脂蛋白（LDL）抗体（OR = 1.96；95% CI 1.05-3.69）和脂质过氧化物（OR = 1.86; 95% CI 1.00-3.50) 在分叉斑块的情况下。总之，PON 1 (LL + ML) 55 但不是 PON 1 (Q/R) 192 或 PON 2 (S/C) 311，似乎是中年女性颈动脉 IMT 增加的独立危险因素。 (C) 2002 Elsevier Science Ireland Ltd. 保留所有权利。
Paraoxonase (PON) gene polymorphisms have been proposed as genetic markers of risk for cardiovascular disease (CVD). Sporadic results suggest they are correlated with intima-media thickness (IMT), an indicator of preclinical atherosclerotic disease. We have investigated whether polymorphisms PON 1 (M/L) 55, (Q/R) 192, PON 2 (S/C) 311 are related to site-specific carotid plaques in 310 middle-aged women. Subjects were also investigated for physical and biochemical parameters including oxidative markers to evaluate their effect on development of atherosclerotic plaques (IMT > 1.2 mm) identified by high resolution B-mode ultrasound. We demonstrate that PON 1 (LL + ML) 55 is associated with plaques both at the bifurcation (OR = 2.40; 95% Cl 1.00-5.90) and at the common carotid artery (OR = 2.75; 95% CI 1.01-7.50), and to the total number of plaques at any site (P < 0.05). This polymorphism is an independent parameter with respect to other variables that are significantly associated with plaques, i.e. systolic blood pressure (OR = 2.06; 95% CI 1.11-3.81) and oxidized low-density lipoprotein (LDL) antibodies (OR = 1.96; 95% Cl 1.05-3.69) in cases of common carotid plaques, and lipid peroxides (OR = 1.86; 95% CI 1.00-3.50) in cases of bifurcation plaques. In conclusion, PON 1 (LL + ML) 55 but not PON 1 (Q/R) 192 or PON 2 (S/C) 311, appears to be an independent risk factor for increased carotid IMT in middle-aged women. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.